PMID: 10425395Jul 30, 1999

The PLD superfamily: insights into catalysis

Biochimica Et Biophysica Acta
M Waite


Knowledge of the PLD superfamily is rapidly expanding and new insights into the mechanism and regulation of the superfamily are rapidly emerging. The recent structural analysis and use of mutant proteins suggest a mechanism that involves two active sites acting in concert. While a number of residues are required for activity, it appears most likely that a histidine is the residue that becomes covalently linked to phosphatidate in catalysis. Evidence for these proposals is covered in this article.


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Related Concepts

Phospholipase D
Substrate Specificity
Homologous Sequences, Amino Acid
Protein Conformation, beta-Strand

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