The pleiotropic effects of ethacrynic acid

American Journal of Therapeutics
John C Somberg, Janos Molnar

Abstract

Ethacrynic acid (EC), an effective loop diuretic especially in patients allergic to sulfa-containing drugs, possesses a number of potentially useful actions in addition to the inhibition of the Na⁺-K⁺-2Cl⁻ kidney symport. Inhibition of the enzyme glutathione S-transferase plays an important role in reducing chemotherapy drug resistance. Chemical modifications of EC increase inhibition of glutathione S-transferase and reduce toxicity due to diuretic action (hypotension and hypovolemia). This work may lead to effective therapies in reducing chemotherapy resistance in cancer chemotherapeutics. In addition, EC or conjurers may be a radiation enhancer, an anti-inflammatory agent, or a treatment for glaucoma.

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Citations

May 15, 2013·Free Radical Biology & Medicine·Michelle Smeyne, Richard Jay Smeyne
May 10, 2016·Expert Opinion on Drug Delivery·Ibrahim A AljuffaliJia-You Fang
Mar 17, 2015·Angewandte Chemie·Jean-Pierre DaguerNicolas Winssinger
Jun 3, 2015·ChemMedChem·Hitesh PatelIrmgard Merfort
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zrinka RajićBranka Zorc
Oct 13, 2020·Molecular Diversity·Ivana PerkovićBranka Zorc

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