The Pleiotropic Effects of GATA1 and KLF1 in Physiological Erythropoiesis and in Dyserythropoietic Disorders

Frontiers in Physiology
Gloria BarbaraniAntonella E Ronchi

Abstract

In the last few years, the advent of new technological approaches has led to a better knowledge of the ontogeny of erythropoiesis during development and of the journey leading from hematopoietic stem cells (HSCs) to mature red blood cells (RBCs). Our view of a well-defined hierarchical model of hematopoiesis with a near-homogeneous HSC population residing at the apex has been progressively challenged in favor of a landscape where HSCs themselves are highly heterogeneous and lineages separate earlier than previously thought. The coordination of these events is orchestrated by transcription factors (TFs) that work in a combinatorial manner to activate and/or repress their target genes. The development of next generation sequencing (NGS) has facilitated the identification of pathological mutations involving TFs underlying hematological defects. The examples of GATA1 and KLF1 presented in this review suggest that in the next few years the number of TF mutations associated with dyserythropoietic disorders will further increase.

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Citations

Nov 27, 2019·IUBMB Life·Laura GutiérrezJohn Strouboulis
Jul 30, 2020·International Journal of Molecular Sciences·Cécile DeleschauxMariano A Ostuni
Jul 28, 2020·Journal of Clinical Medicine·Matthew CannonRosa Lapalombella
Jan 31, 2020·Malaria Journal·Denis DelicMarcos J Araúzo-Bravo
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Gloria BarbaraniAntonella E Ronchi
Jun 29, 2021·Journal of Cellular and Molecular Medicine·Shinji KondoHiroko Isoda
Aug 1, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer M FeltonMarc E Rothenberg

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Methods Mentioned

BETA
MDS
exome sequencing
gene knockouts
two-hybrid
transgenic
FACS

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