Oct 1, 1989

The pluripotential nature of the mesenchyme-like component of yolk sac tumor

Archives of Pathology & Laboratory Medicine
H MichaelC A Brodhecker


Germ cell neoplasms were reviewed for the investigation of a mesenchyme-like component of yolk sac tumor (YST) characterized by spindle cells with few mitoses in a myxoid, vascular background. Nineteen YSTs with this pattern were identified. The mesenchyme-like component of these YSTs appeared to derive from the epithelial elements of YST, since cytokeratin as well as vimentin positivity occurred in the spindle cells of the mesenchyme-like areas and foci of epithelial-spindle cell transition were present. In some cases the mesenchyme-like component showed differentiated mesenchymal elements (usually skeletal muscle). Similar features were identified in 13 chemotherapy-treated cases of YST that consisted only of this mesenchyme-like component. The mesenchyme-like component of YST appears to represent a chemoresistant, pluripotential cell population arising from metaplasia of YST epithelium; it may give rise to sarcomas occurring in some patients with treated germ cell tumors.

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Mentioned in this Paper

Ovarian Neoplasm
Neoplasms, Germ Cell and Embryonal
Malignant Mesenchymal Tumor
Keratin-Associated Proteins
Malignant Neoplasm of Testis

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