The Pneumovirinae fusion (F) protein: A common target for vaccines and antivirals

Virus Research
José A Melero, Vicente Mas

Abstract

The Pneumovirinae fusion (F) protein mediates fusion of the virus and cell membrane, an essential step for entry of the viral genome in the cell cytoplasm and initiation of a new infectious cycle. Accordingly, potent inhibitors of virus infectivity have been found among antibodies and chemical compounds that target the Pneumovirinae F protein. Recent developments in structure-based vaccines have led to a deeper understanding of F protein antigenicity, unveiling new conformations and epitopes which should assist in development of efficacious vaccines. Similarly, structure-based studies of potent antiviral inhibitors have provided information about their mode of action and mechanisms of resistance. The advantages and disadvantages of the different options to battle against important pathogens, such as human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are summarized and critically discussed in this review.

References

Apr 1, 1991·The Journal of Infectious Diseases·C B HallK C Schnabel
Sep 1, 1987·The Journal of General Virology·S LevineP R Paradiso
Jun 1, 1986·American Journal of Diseases of Children·W P GlezenJ A Kasel
Jul 10, 1986·The New England Journal of Medicine·C B HallH J Cohen
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G W WertzL A Ball
Jan 1, 1982·Antimicrobial Agents and Chemotherapy·J F HruskaR G Douglas
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M LambertS R Petteway
Feb 18, 1998·The Journal of Infectious Diseases·A R Falsey, E E Walsh
Oct 24, 2000·Journal of Virology·L K HallakM E Peeples
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·L González-ReyesJ A Melero
Nov 26, 2003·Antiviral Research·Koen AndriesPhilip R Wyde
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·Christopher CianciMark Krystal
Oct 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher CianciMark Krystal
Dec 28, 2004·Nature Medicine·Vira BitkoSailen Barik
Apr 29, 2005·The New England Journal of Medicine·Ann R FalseyEdward E Walsh
May 27, 2005·Antimicrobial Agents and Chemotherapy·Janet L DouglasTomas Cihlar
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fernando P PolackSteven R Kleeberger
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hsien-Sheng YinTheodore S Jardetzky
Jun 20, 2007·Antimicrobial Agents and Chemotherapy·Joanna ChapmanKenneth L Powell
Oct 31, 2007·Antimicrobial Agents and Chemotherapy·Céline DeffrasnesGuy Boivin
Nov 15, 2008·The Journal of General Virology·Nancy D UlbrandtMichael P McCarthy
Aug 27, 2009·Biologics : Targets & Therapy·Asunción Mejías, Octavio Ramilo
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dirk RoymansKoen Andries

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Citations

Apr 6, 2016·PloS One·Jin Il KimKi-Joon Song
Nov 17, 2017·Nature Communications·Michael B BattlesJason S McLellan
Dec 9, 2017·EMBO Molecular Medicine·Eduardo OlmedillasVicente Más
Feb 26, 2020·Pathogens·Daniela Ogonczyk MakowskaGuy Boivin
Nov 10, 2018·Journal of Medicinal Chemistry·G Stuart CockerillNeil Mathews

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