The Polemic Diagnostic Role of TP53 Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers

Cancers
M Carmen Garrido-NavasM Jose Serrano

Abstract

Being minimally invasive and thus allowing repeated measures over time, liquid biopsies are taking over traditional solid biopsies in certain circumstances such as those for unreachable tumors, very early stages or treatment monitoring. However, regarding TP53 mutation status analysis, liquid biopsies have not yet substituted tissue samples, mainly due to the lack of concordance between the two types of biopsies. This needs to be examined in a study-dependent manner, taking into account the particular type of liquid biopsy analyzed, that is, circulating tumor cells (CTCs) or cell-free DNA (cfDNA), its involvement in the tumor biology and evolution and, finally, the technology used to analyze each biopsy type. Here, we review the main studies analyzing TP53 mutations in either CTCs or cfDNA in the three more prevalent solid tumors: breast, colon and lung cancers. We evaluate the correlation for mutation status between liquid biopsies and tumor tissue, suggesting possible sources of discrepancies, as well as evaluating the clinical utility of using liquid biopsies for the analysis of TP53 mutation status and the future actions that need to be undertaken to make liquid biopsy analysis a reality for the evaluation of TP53 mutations.

References

Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Feb 14, 2006·American Journal of Clinical Pathology·Andre M OliveiraJonathan A Fletcher
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
Oct 4, 2014·Oncotarget·Maria J SerranoJose A Lorente
Oct 14, 2014·Breast Cancer Research : BCR·Sandra V FernandezMassimo Cristofanilli
Jun 19, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean Sebastien FrenelJohann S de Bono
Oct 2, 2015·EBioMedicine·Daniela KandiolerUNKNOWN p53 Research Group and the Austrian Breast and Colorectal Study Group (ABCSG)
Jun 9, 2016·Oncotarget·Maurice Phm JansenEls Mjj Berns
Jul 6, 2016·EBioMedicine·Lynnette Fernandez-CuestaPaul Brennan
Oct 6, 2016·International Journal of Molecular Sciences·Zhaomei MuMassimo Cristofanilli
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matteo CanalePaola Ulivi
Mar 3, 2017·Nature Reviews. Clinical Oncology·Giulia SiravegnaAlberto Bardelli
Mar 9, 2017·Breast Cancer Research and Treatment·Catherine BinghamR Katherine Alpaugh
Apr 11, 2017·Chemical Society Reviews·Zheyu ShenXiaoyuan Chen
May 14, 2017·Breast Cancer Research and Treatment·Kara N MaxwellAngela DeMichele
May 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Filip JankuNeeraj S Salathia
Aug 7, 2017·Molecular and Clinical Oncology·Zongbi YiFei Ma
Aug 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzJames N Ingle
Nov 29, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giovanna RossiMassimo Cristofanilli
Feb 18, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Hiroyasu FurukiEiji Uchida
Mar 24, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuebi HuGeoffrey R Oxnard
Jun 20, 2018·Bioscience Reports·Ying-Chi YangZhong-Tao Zhang
Aug 30, 2018·Frontiers in Oncology·Joanna KapelerisChamindie Punyadeera
Dec 7, 2018·Journal of Molecular Cell Biology·Xiang ZhouHua Lu
Dec 13, 2018·Cell Death and Differentiation·Fiamma MantovaniGiannino Del Sal

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Methods Mentioned

BETA
biopsies
genotyping
PCR
biopsy

Clinical Trials Mentioned

NCT02965950
NCT03544723

Software Mentioned

CancerSeek
CellSearch

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