The Polish Intestinal Failure Centres' consensus on the use of teduglutide for the treatment of short bowel syndrome

Nutrition
Stanisław KlekKrystyna Urbanowicz

Abstract

Teduglutide is an active, glucagon-like peptide (GLP)-2 analog with proven clinical efficacy regarding intestinal adaptation in patients with short bowel syndrome (SBS). There are two factors that preclude its reimbursement, and thereby, its availability: its cost (reaching ∼$300,000/y)-which significantly exceeds the cost of home parenteral nutrition (HPN) in most countries-and the lack of clear guidelines. The aim of this study was to create evidence-based working criteria for the use of teduglutide that could be used in clinical settings. Experts from the Polish Network of Intestinal Failure Centers analyzed available research and considered experience on the topic of HPN and intestinal failure to create guidelines. Experts agreed that there are two groups of HPN patients who can benefit from therapy with a GLP-2 analog: those with a good prognosis (in whom complete weaning from HPN may be possible) and those with a poor prognosis (the therapy would be lifesaving). Patient criteria comprise the following: inclusion and exclusion criteria, parameters that can be used for monitoring, outcome measures, and the rationale for the termination of the treatment. It was possible to describe inclusion criteria for both patient groups ...Continue Reading

Citations

Nov 6, 2018·Journal of Pain & Palliative Care Pharmacotherapy·Shana SemmensPatrick Coyne
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Augusto Lauro, Florence Lacaille

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