The POLISMAIL lesson: sublingual immunotherapy may be prescribed also in polysensitized patients

International Journal of Immunopathology and Pharmacology
G CiprandiF Frati

Abstract

Polysensitization is a feature of allergic rhinitis (AR) that significantly impairs the quality of life (QoL) of AR patients. Allergen-specific immunotherapy is the only causal therapy for AR. However, the polysensitization phenomenon may represent a crucial obstacle as far as it concerns the choice of the allergen extract which should be used for immunotherapy. Therefore, a real-life based multi-centre study, named POLISMAIL, has been designed which aims at evaluating the behaviour of some allergists managing polysensitized AR patients. The effect of two-year SLIT treatment in those patients was also evaluated. A single allergen extract was used for two-thirds of patients, whereas a mix of two allergens was chosen for the remaining patients. The severity grade of AR and the type of diagnosis were significantly improved by 2-year SLIT. In addition, SLIT significantly improved QoL. Both outcomes confirm that SLIT with one or two allergen extracts achieves a significant improvement in polysensitized patients. In conclusion, the POLISMAIL study demonstrates that polysensitization should not represent a counter-indication for prescribing immunotherapy. The choice to limit SLIT to 1-2 allergen extracts was sufficient and effective i...Continue Reading

References

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Citations

Jan 20, 2011·International Journal of Immunopathology and Pharmacology·G CiprandiG L Marseglia
Dec 24, 2013·Current Opinion in Allergy and Clinical Immunology·Giovanni Passalacqua
May 22, 2020·Immunotherapy·Nerin N Bahceciler, Ozel Yuruker
Feb 24, 2015·Clinical and Translational Allergy·Carmen VidalUNKNOWN Expert Clinical Participants
Mar 19, 2015·American Journal of Rhinology & Allergy·Stella LeeMichael S Benninger
Jun 5, 2014·Immunotherapy·Erminia RidoloCristoforo Incorvaia
Jul 28, 2011·Expert Review of Clinical Immunology·Jison Hong, Leonard Bielory
Jul 7, 2015·Expert Review of Clinical Immunology·Giorgio CiprandiUNKNOWN Italian Study Group on Polysensitization
Jan 14, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Pascal DemolyUlrich Wahn
Feb 19, 2013·Immunotherapy·Nerin Nadir BahcecilerNazan Cobanoglu

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