The pollen extract Femal--a nonestrogenic alternative to hormone therapy in women with menopausal symptoms

Menopause : the Journal of the North American Menopause Society
Ann-Cathrin Hellström, Jonas Muntzing

Abstract

Hormone therapy with estrogen alone or combined with progestogen has come into disrepute because of safety concerns. Herbal medicinal products with an estrogenic action caused by their content of phytoestrogens constitute an alternative therapy. However, the estrogenic adverse effects of such products have caused some concern. The pollen extract Femal has been shown to be effective in the treatment of menopausal symptoms like hot flushes and sleeplessness. The present investigation was undertaken to examine if this pollen extract preparation contained phytoestrogens in a concentration sufficient to give the preparation an estrogenic effect. Samples of the pollen extract in Femal were subjected to high-performance liquid chromatography analyses of phytoestrogens. The pollen extract was tested for estrogenic activity in the immature rat uterotropic bioassay. The pollen extracts were found to contain low, subeffective concentrations of daidzin, daidzein, and genistin. Genistein, formononetin, and biochanin A could not be detected. Pollen extract in the high dose of 500 mg kg day did not cause any uterine growth in immature female rats. The results show that the pollen extract in Femal does not give the preparation any estrogenic e...Continue Reading

References

Jul 1, 1988·Acta Psychiatrica Scandinavica·M MauriA W MacLean
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M Jouvet
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Boulant
Nov 1, 1992·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T Habeshaw, S B Pinion
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vered Stearns, Daniel F Hayes
Nov 20, 2002·Menopause : the Journal of the North American Menopause Society
May 27, 2005·Journal of Women's Health·Tara W StrineIndu B Ahluwalia
May 9, 2007·Menopause : the Journal of the North American Menopause Society·Robert R Freedman, Timothy A Roehrs
Dec 19, 2009·Maturitas·Piksi Singh, Martin K Oehler
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Kurt Krauchi, Tom Deboer
Sep 16, 2010·Annals of the New York Academy of Sciences·Farook Al-Azzawi, May Wahab
Jun 1, 2010·International Health·Phaik Yeong CheahFrançois Nosten

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Citations

May 17, 2013·Metabolomics : Official Journal of the Metabolomic Society·Angela MariWolfram Weckwerth
Sep 24, 2015·Expert Opinion on Pharmacotherapy·Santiago Palacios, Andrea Mejias
Jul 15, 2015·Molecular and Clinical Oncology·Karsten MünstedtJutta Hübner
Sep 1, 2015·Endocrinology and Metabolism Clinics of North America·Maida Taylor
Jun 18, 2014·Journal of Holistic Nursing : Official Journal of the American Holistic Nurses' Association·Ashley M Henneghan, Tracie Harrison
Nov 29, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Harald SeegerAlfred O Mueck
Nov 28, 2017·The Nurse Practitioner·Diane Todd Pace
Mar 15, 2019·Journal of Evidence-based Integrative Medicine·Alisa JohnsonGary Elkins
Feb 6, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Andrea GenazzaniSantiago Palacios
Jul 17, 2020·Archives of Gynecology and Obstetrics·Karsten Münstedt, Heidrun Männle
Jul 30, 2019·Frontiers in Pharmacology·Chen YuYang Wang
Apr 8, 2020·Archives of Pharmacal Research·Anowarul IslamMd Rashedunnabi Akanda
Feb 12, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tomas FaitPedro-Antonio Regidor
Jul 27, 2021·Expert Opinion on Drug Safety·Pasquale De FranciscisNicola Colacurci
Aug 15, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Nese YukselMichel Fortier

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