The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology.

Nature Reviews. Neurology
Olav B SmelandOle A Andreassen

Abstract

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality. Although the past two decades have seen limited improvement in the treatment of schizophrenia, research into the genetic causes of this condition has made important advances that offer new insights into the aetiology of schizophrenia. This Review summarizes the evidence for a polygenic architecture of schizophrenia that involves a large number of risk alleles across the whole range of population frequencies. These genetic risk loci implicate biological processes related to neurodevelopment, neuronal excitability, synaptic function and the immune system in the pathogenesis of schizophrenia. Mathematical models also suggest a substantial overlap between schizophrenia and psychiatric, behavioural and cognitive traits, a situation that has implications for understanding its clinical epidemiology, psychiatric nosology and pathobiology. Looking ahead, further genetic discoveries are expected to lead to clinically relevant predictive approaches for identifying high-risk individuals, improved diagnostic accuracy, increased yield from drug development programmes and improved stratification strategies to address the heterogeneous disease course and ...Continue Reading

References

Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Sep 19, 1987·British Medical Journal·R M Murray, S W Lewis
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Dec 1, 1995·Archives of General Psychiatry·J W Olney, N B Farber
Sep 13, 1996·Science·N Risch, K Merikangas
Feb 19, 1998·Schizophrenia Research·T J Crow
Oct 26, 1999·Archives of General Psychiatry·K C MurphyM J Owen
Jan 13, 2000·Archives of General Psychiatry·L A Glantz, D A Lewis
Jul 2, 2002·The American Journal of Psychiatry·Mary CannonRobin M Murray
Jun 13, 2003·American Journal of Human Genetics·Cathryn M LewisTomas Helgason
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A CARLSSON, M LINDQVIST
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Jun 3, 2004·JAMA : the Journal of the American Medical Association·Koen DemyttenaereUNKNOWN WHO World Mental Health Survey Consortium
Dec 31, 2004·The American Journal of Psychiatry·Elizabeth Cantor-Graae, Jean-Paul Selten
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanUNKNOWN Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
Aug 24, 2006·International Journal of Epidemiology·Per MagnusUNKNOWN MoBa Study Group
Nov 11, 2006·The Behavioral and Brain Sciences·Matthew C Keller, Geoffrey Miller
Mar 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Jon M McClellanMary-Claire King
Aug 31, 2007·Nature Genetics·UNKNOWN GAIN Collaborative Research GroupFrancis S Collins
Dec 18, 2007·Cell·Beth StevensBen A Barres
Aug 1, 2008·Nature·Hreinn StefanssonKari Stefansson
Aug 5, 2008·Nature Genetics·Michael C O'DonovanUNKNOWN Molecular Genetics of Schizophrenia Collaboration
Nov 13, 2008·Molecular Psychiatry·UNKNOWN Psychiatric GWAS Consortium Steering Committee
Mar 28, 2009·Schizophrenia Bulletin·Oliver D Howes, Shitij Kapur
Apr 8, 2009·Molecular Psychiatry·M Y M NgC M Lewis
Jul 3, 2009·Nature·Hreinn StefanssonDavid A Collier
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Feb 4, 2010·The American Journal of Psychiatry·Alan S Brown, Elena J Derkits
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Nov 12, 2010·Nature·Thomas R Insel
Nov 12, 2010·Nature·Jim van OsBart P F Rutten
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Feb 1, 2011·Neuropharmacology·Kazu NakazawaJuan E Belforte
Feb 9, 2011·Archives of General Psychiatry·Beng-Choon HoVincent Magnotta
Mar 8, 2011·American Journal of Human Genetics·Sang Hong LeePeter M Visscher
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Sep 20, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anders GustavssonUNKNOWN CDBE2010Study Group
Sep 20, 2011·Nature Genetics·UNKNOWN Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium

❮ Previous
Next ❯

Citations

Aug 17, 2020·Biomolecules·Jo Soo HyunAkiko Hayashi-Takagi
Oct 22, 2020·Brain Sciences·Samskruthi Madireddy, Sahithi Madireddy
Dec 2, 2020·The American Journal of Psychiatry·Joseph T CoyleDarrick T Balu
Nov 3, 2020·Frontiers in Psychiatry·Silvia Sánchez-Ramón, Florence Faure
Jan 1, 2021·The Indian Journal of Medical Research·Tilman Steinert
Mar 7, 2021·International Journal of Molecular Sciences·Kah Kheng GohHsien-Yuan Lane
May 11, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Isabella CostamagnaRobert Goldman
Jun 7, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Olav B Smeland, Ole A Andreassen
Jun 24, 2021·JAMA Psychiatry·Weiqiu ChengOle A Andreassen
Jul 25, 2021·Translational Psychiatry·Linn RødevandOle A Andreassen
Jul 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Matthieu GasnierPierre Abdel Ahad
Aug 21, 2021·Psychological Medicine·Annabell CoorsUlrich Ettinger
Sep 1, 2021·Molecular Psychiatry·Eva-Maria StaufferEdward T Bullmore
Jul 7, 2021·Translational Psychiatry·Kristin TorgersenOle A Andreassen
Jul 18, 2021·Brain : a Journal of Neurology·Shahram BahramiOle A Andreassen

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
genotyping
exome-sequencing

Software Mentioned

iPSYCH
MiXeR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Psychiatry
R W Gerard
Current Opinion in Psychiatry
Dragan M SvrakicClaude R Cloninger
The Psychiatric Clinics of North America
Pablo V GejmanJubao Duan
© 2022 Meta ULC. All rights reserved