PMID: 11030626Oct 13, 2000

The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells

J R ZhangElaine I Tuomanen


The polymeric immunoglobulin receptor (pIgR) plays a crucial role in mucosal immunity against microbial infection by transporting polymeric immunoglobulins (pIg) across the mucosal epithelium. We report here that the human pIgR (hpIgR) can bind to a major pneumococcal adhesin, CbpA. Expression of hpIgR in human nasopharyngeal cells and MDCK cells greatly enhanced pneumococcal adherence and invasion. The hpIgR-mediated bacterial adherence and invasion were abolished by either insertional knockout of cbpA or antibodies against either hpIgR or CbpA. In contrast, rabbit pIgR (rpIgR) did not bind to CbpA and its expression in MDCK cells did not enhance pneumococcal adherence and invasion. These results suggest that pneumococci are a novel example of a pathogen co-opting the pIg transcytosis machinery to promote translocation across a mucosal barrier.


Feb 18, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J A ThorntonElaine I Tuomanen
Jul 26, 2005·Journal of Biomolecular NMR·Rensheng LuoRichard W Kriwacki
Sep 29, 2001·International Journal of Pediatric Otorhinolaryngology·Y TsuboiJ Lin
Sep 21, 2002·International Journal of Pediatric Otorhinolaryngology·Jizhen LinYoungki Kim
Jan 22, 2002·Trends in Neurosciences·Roland Nau, Wolfgang Brück
Feb 15, 2001·Current Opinion in Microbiology·Susan K Hollingshead, David E Briles
Mar 5, 2003·Current Opinion in Microbiology·Beth A McCormick
Jan 28, 2003·Trends in Immunology·Armelle Phalipon, Blaise Corthésy
Jan 23, 2010·Epidemiology and Infection·I BurckhardtR R Reinert
Mar 15, 2008·Nature Reviews. Microbiology·A KadiogluPeter W Andrew
Mar 24, 2004·Nature Reviews. Microbiology·Timothy J Mitchell
Jan 6, 2010·The Journal of Biological Chemistry·Salvatore PapasergiConcetta Beninati
May 28, 2010·The Journal of Biological Chemistry·Vaibhav AgarwalSven Hammerschmidt
Jul 10, 2009·The Journal of Infectious Diseases·Ernesto HinojosaCarlos J Orihuela
May 17, 2002·Current Opinion in Infectious Diseases·Damian N MeliMartin G Täuber
Aug 17, 2006·Journal of Gastroenterology and Hepatology·Ashlesh K MurthyBernard P Arulanandam
Jul 22, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Gavin K Paterson, Carlos J Orihuela
Mar 25, 2010·Molecular Oral Microbiology·A KadiogluH F Jenkinson
Jul 5, 2012·Molecular Oral Microbiology·I Pérez-DoradoJ A Hermoso
Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek
Jan 14, 2009·Infection and Immunity·Carolyn MarionSamantha J King
Sep 13, 2001·Infection and Immunity·A David OgunniyiJames C Paton
Apr 23, 2004·Infection and Immunity·Francesco IannelliGianni Pozzi


Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Apr 8, 1985·Journal of Immunological Methods·M P WoodwardR A Bloodgood
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J G Tiraby, M S Fox
Jan 1, 1981·Annual Review of Microbiology·P C McNabb, T B Tomasi
Feb 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K E Mostov, M H Cardone
Sep 1, 1994·Genes & Development·P L SteinP Soriano
Jan 1, 1994·Annual Review of Immunology·K E Mostov
Jun 1, 1994·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·D C Knockaert
May 16, 1998·Molecular Biology of the Cell·K L Singer, K E Mostov
Jul 17, 1998·The Journal of Clinical Investigation·A RingElaine I Tuomanen
Apr 14, 1999·Molecular Microbiology·J R ZhangElaine I Tuomanen

Related Concepts

Heat shock proteins
Adhesins, Bacterial
Nasal Epithelium
Bacterial Proteins
Polymeric Immunoglobulin Receptors
Pathogenic Organism
G-Protein-Coupled Receptors
Hormone Receptors, Cell Surface
Squamous Transitional Epithelial Cell Count

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.