The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles sinensis in the Republic of Korea.

Malaria Journal
Seunghyun KangWon Kim

Abstract

In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and spread of insecticide resistance in the An. sinensis complex. Knockdown resistance (kdr) to pyrethroids and DDT in the An. sinensis complex is associated with a mutation in codon 1014 of the voltage-gated sodium channel (VGSC) gene. Because the degree of insecticide resistance varies among mosquito species and populations, the detection of kdr mutations among the six sibling species of the An. sinensis complex is a prerequisite for establishing effective long-term vector control strategies in the ROK METHODS: In order to investigate species-specific kdr mutations, An. sinensis complex specimens have been collected from 22 sites in the ROK. Because of the difficulties with species identifications that are based only on morphological characteristics, molecular identification methods have been conducted on every specimen. Part of the IIS6 domain of the VGSC was polymerase chain reaction-amplified and directly sequenced. The molecula...Continue Reading

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Citations

Apr 30, 2014·Journal of the American Mosquito Control Association·Siriporn PhasomkusolsilTerry A Klein
Apr 19, 2015·Malaria Journal·Hong-wei ZhangBian-li Xu
Feb 16, 2021·Genomics·Yu-Juan ZhangBin Chen

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
PCR

Software Mentioned

Clustal X
MEGA
Sequence Navigator

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