PMID: 9448289Mar 14, 1998Paper

The polyoma virus T antigen interferes with interferon-inducible gene expression

Proceedings of the National Academy of Sciences of the United States of America
X WeihuaD V Kalvakolanu

Abstract

Murine polyoma virus (MPyV) is a small DNA virus that induces tumors in multiple tissues of infected host. In this investigation, we show that cell lines derived from wild type virus-induced breast tumors are resistant to the growth inhibitory action of interferon beta (IFN-beta). Furthermore, replication of heterologous viruses such as vesicular stomatitis virus and encephalomyocarditis virus was not inhibited by IFN-beta in these cells. This effect was due to inhibition of IFN-stimulated gene expression by viral T antigen. Activation of IFN-stimulated gene factor 3 was inhibited in cells derived from a tumor induced by wild-type MPyV but not those from a mutant that lacks the pRB binding site of the large T antigen. Similarly IFN-gamma-inducible gene expression was also inhibited in cells transformed by wild-type virus. The levels of components of IFN-stimulated gene factor 3 and signal transducing Janus tyrosine kinases were comparable between the cells transformed by the wild-type and mutant viruses. The viral large T antigen bound to Janus tyrosine kinase 1 and inactivated signaling through IFN receptors. Thus, these studies identify a mechanism of viral resistance to IFN action.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D ResnitzkyA Kimchi
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R Kumar, I Atlas
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D V KalvakolanuG C Sen
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J Gutch, N C Reich
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G R FosterG R Stark
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·V CheringtonT M Roberts
Jan 1, 1996·Cancer Investigation·D V Kalvakolanu, E C Borden
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F BrombergJ E Darnell
Sep 1, 1996·Endocrinology·P E LobieG Morel
Sep 26, 1996·Nature·S BhattacharyaD M Livingston
Oct 1, 1996·Virology·G T Leonard, G C Sen
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·X WeihuaD V Kalvakolanu

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Citations

Nov 1, 2002·Reviews in Medical Virology·Bin GotohJunko Yokoo
Apr 28, 2004·Cytokine & Growth Factor Reviews·Dhananjaya V Kalvakolanu
Oct 11, 2003·Pharmacology & Therapeutics·Dhananjaya V Kalvakolanu
Apr 28, 2001·Cytokine & Growth Factor Reviews·D E Levy, A García-Sastre
Jan 27, 2005·Viral Immunology·Friedemann WeberOtto Haller
May 9, 2000·Journal of Virology·Q ShengB Schaffhausen
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·K A Gottlieb, L P Villarreal
Jan 20, 2011·PLoS Neglected Tropical Diseases·A M A NasirudeenDing Xiang Liu
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jorge L Muñoz-JordanAdolfo García-Sastre
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
Aug 23, 2019·Scientific Reports·Florian SonthonnaxHervé Bourhy
Sep 20, 2000·The Journal of General Virology·S GoodbournR E Randall
Oct 22, 2020·Cellular and Molecular Life Sciences : CMLS·José M RojasNoemí Sevilla
Aug 28, 2020·Journal of Virology·Angela R Harrison, Gregory W Moseley
Apr 28, 1999·Trends in Microbiology·D V Kalvakolanu
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M Kumar, G G Carmichael

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