The pony as an animal model for vascular implants

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
C Wagner-MannJ Conti

Abstract

This study evaluated the pony as a potentially suitable model for vascular implant research. Healthy, conditioned ponies were randomly assigned to one of three groups: group I, carotid artery autografts (n = 6); group II, e-PTFE carotid interpositional grafts (n = 5); and group III, e-PTFE carotid interpositional grafts plus aspirin (10 mg/kg) and dipyridamole (3.5 mg/kg) drug administration. It was found that autografts remained patent longest (mean = 396.2 days; grafts were still patent at time of writing) followed by group III grafts (157.5 days), with group II grafts remaining patent for the shortest duration (61.1 days), (p less than 0.01). Patency was determined using two-dimensional real-time ultrasonography with Doppler velocimetry and/or arteriography. It was demonstrated that the pony's response to antithrombotic drugs was consistent and comparable to that in other animal models, both with respect to platelet function and affect on patency rate. The combination of the ease of surgical manipulation, drug administration, and platelet function testing, the comparable size of the pony and its heart and blood vessels to that of an adult human, the long life span of ponies, and the patency results of this study have demonst...Continue Reading

References

Oct 1, 1987·Cardiovascular Research·K S RughJ R Miramonti
Dec 1, 1986·The American Journal of Cardiology·D LauriG de Gaetano
Dec 1, 1985·American Journal of Surgery·B L McCroskeyG E Pierce
Nov 1, 1974·Archives of Surgery·L R SauvageP B Mansfield
Feb 1, 1982·The Journal of Surgical Research·M B HerringJ Glover

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