The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation

Cancer Medicine
Qinchao HuBin Cheng

Abstract

Radiotherapy for nasopharyngeal carcinoma has been reported to cause second primary oral squamous cell carcinoma (s-OSCC). The prognosis and pathologic characteristic of s-OSCC are largely unknown. Bmi1 was associated with the repair of radiation-induced DNA damage, suggesting its possible involvement in the pathologic process of s-OSCC. Herein, we compared the prognosis between s-OSCC and primary OSCC (p-OSCC) and explored the involvement of Bmi1 in s-OSCC development. In this retrospective study, s-OSCC and p-OSCC patients were matched by propensity scores. Their outcomes were compared by univariate and multivariate analyses. The expression of Bmi1 in s-OSCC and p-OSCC was detected by immunohistochemistry (IHC). Radiation-induced Bmi1 alteration in early-stage was explored in a rat model and HaCaT cells. After matching, 116 pairs of patients with highly balanced characteristics were included. In univariate analysis, the overall survival (OS), disease-specific survival (DSS), and local recurrence-free survival (LRFS) were poorer in s-OSCC than in p-OSCC (P < 0.05), while their regional metastasis-free survival (RMFS) was parallel (P = 0.112). Multivariate analysis further revealed that radiotherapy history was an independent r...Continue Reading

References

Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P M TeoP J Johnson
Apr 2, 2004·Nature Reviews. Cancer·Stephen T Sonis
Aug 5, 2005·The Oncologist·Boudewijn J M BraakhuisC René Leemans
Jan 24, 2007·Cancer Causes & Control : CCC·Ghislaine ScéloPaul Brennan
Feb 2, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M-C ChenK-D Lee
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jennifer Shepard DoveyJacqueline A Lees
May 20, 2009·Annals of Surgical Oncology·Iris M C van der PloegEmiel J T Rutgers
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jul 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tetsuhiro ChibaAtsushi Iwama
Jan 5, 2011·Medicina oral, patología oral y cirugía bucal·Chun-Yang LiBin Cheng
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 9, 2011·Molecular and Cellular Biology·Vasudeva GinjalaShridar Ganesan
Sep 14, 2012·CA: a Cancer Journal for Clinicians·Joel B EpsteinEllie Maghami
Mar 27, 2013·Nature Reviews. Clinical Oncology·Lois B TravisAndrea K Ng
May 4, 2013·Annals of Diagnostic Pathology·Lihua MaZengtong Zhou
Oct 7, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhongwu LiJie Cheng
Feb 14, 2015·International Journal of Biological Sciences·Zhi-Yuan XuXiang-Dong Cheng
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
Dec 19, 2015·Genes & Development·Roberta FerrettiJacqueline A Lees
Mar 10, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gerald Ci-An TayHiang Khoon Tan

❮ Previous
Next ❯

Software Mentioned

Image J
SPSS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.