The population biology of the interaction between HIV-1 and HIV-2: coexistence or competitive exclusion?

AIDS
R M Anderson, R M May

Abstract

The emergence and rapid world-wide spread of HIV provides an unusual opportunity for the study of the evolution and maintenance of virulence in a major human pathogen. To analyse the available biological and epidemiological data on the pathogenicity, transmissibility and antigenic similarity of HIV-1 and HIV-2, and use simple mathematical models of competition between the two viral types within a defined host community. Analysis revealed a positive association between pathogenicity and reproductive success. A mathematical model of the concomitant transmission of the two viruses suggests that HIV-1 will competitively displace HIV-2 in the longer term in areas where both viruses are being transmitted within the same sexually active population.

Citations

Oct 30, 2012·International Journal of STD & AIDS·K HeitzingerUNKNOWN University of Washington-Dakar HIV and Cervical Cancer Study Group
Dec 21, 2010·Methods : a Companion to Methods in Enzymology·Brandon S Razooky, Leor S Weinberger
Oct 21, 2015·AIDS·Helen R FryerThushan I de Silva
Jul 9, 2004·AIDS·Kimber L GrossRobert M Grant
Jun 9, 2001·Biological Reviews of the Cambridge Philosophical Society·E C Holmes
Oct 27, 2007·AIDS Research and Human Retroviruses·Donald J HamelPhyllis J Kanki
Jun 19, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R M MayA R McLean

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