The population history of endogenous retroviruses in mule deer (Odocoileus hemionus)

The Journal of Heredity
Pauline L KamathMary Poss

Abstract

Mobile elements are powerful agents of genomic evolution and can be exceptionally informative markers for investigating species and population-level evolutionary history. While several studies have utilized retrotransposon-based insertional polymorphisms to resolve phylogenies, few population studies exist outside of humans. Endogenous retroviruses are LTR-retrotransposons derived from retroviruses that have become stably integrated in the host genome during past infections and transmitted vertically to subsequent generations. They offer valuable insight into host-virus co-evolution and a unique perspective on host evolutionary history because they integrate into the genome at a discrete point in time. We examined the evolutionary history of a cervid endogenous gammaretrovirus (CrERVγ) in mule deer (Odocoileus hemionus). We sequenced 14 CrERV proviruses (CrERV-in1 to -in14), and examined the prevalence and distribution of 13 proviruses in 262 deer among 15 populations from Montana, Wyoming, and Utah. CrERV absence in white-tailed deer (O. virginianus), identical 5' and 3' long terminal repeat (LTR) sequences, insertional polymorphism, and CrERV divergence time estimates indicated that most endogenization events occurred within ...Continue Reading

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Citations

Aug 11, 2016·Molecular Biology and Evolution·Tomáš HronDaniel Elleder
Apr 10, 2019·Nature Reviews. Microbiology·Welkin E Johnson
Sep 5, 2021·Molecular Biology and Evolution·Lei YangMary Poss

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