The porcine and lagomorph septal cartilages: models for tissue engineering and morphologic cartilage research

American Journal of Rhinology
B J WongJ S Nelson

Abstract

Interest in reconstruction and modification of the facial cartilaginous frameworks using advanced technology and instrumentation is growing rapidly. Despite this maturing interest, no animal model has been established to provide morphologic cartilage tissue with similar characteristics to human septum in suitable quantities. The objective of this study was to characterize porcine and lagomorph (rabbit) nasal septal cartilage tissue. Both models share great similarity with their human counterpart and provide a low-cost, high-volume, and easily obtained source of bulk cartilage tissue. We present a technique for harvesting intact septal cartilages from these species, and characterize select cellular, metabolic, and physical properties using pulse-chase radiolabeling, flow cytometry, and mechanical analysis. Our selective evaluation of key tissue properties establishes these species as appropriate animal models for nasal septal cartilaginous surgery.

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Citations

Sep 16, 2010·Annals of Biomedical Engineering·Dmitry E ProtsenkoBrian J F Wong
Jul 9, 2010·Annals of Biomedical Engineering·Cyrus T ManuelBrian J F Wong
Oct 18, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ji-Hun MoYoung-Jun Chung
Nov 7, 2003·The Laryngoscope·Ki-Hong Kevin HoBrian J F Wong
Feb 2, 2006·Annals of Biomedical Engineering·Dmitriy E ProtsenkoBrian J F Wong
Sep 18, 2008·Lasers in Surgery and Medicine·Ick-Soo ChoiBrian Wong
Feb 5, 2003·Physics in Medicine and Biology·Sergio H DíazBrian J F Wong
Mar 22, 2006·Archives of Facial Plastic Surgery·Amir M KaramBrian J F Wong
Sep 28, 2006·The Laryngoscope·Meghann L KaiserBrian J Wong
Dec 18, 2013·JAMA Facial Plastic Surgery·Allen FouladBrian J Wong
Jun 27, 2013·Clinical and Experimental Otorhinolaryngology·Ji-Hun MoYoung-Jun Chung
Aug 14, 2012·Lasers in Surgery and Medicine·Allison J ZemekBrian J F Wong
May 5, 2017·JAMA Facial Plastic Surgery·Karam W BadranBrian J F Wong
Mar 14, 2019·The Annals of Otology, Rhinology, and Laryngology·Nikita GuptaJames C Iatridis
Jan 21, 2003·Archives of Facial Plastic Surgery·Michael W KeefeBrian J F Wong
Sep 12, 2012·The Laryngoscope·Christian CondermanBrian J F Wong
Sep 13, 2012·Laboratory Animals·J ŠtembírekM Buchtová
May 19, 2005·Lasers in Surgery and Medicine·Brian J F WongDavid Gardiner
Feb 18, 2017·European Annals of Otorhinolaryngology, Head and Neck Diseases·J R GandyB J F Wong

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