PMID: 11921285Mar 29, 2002Paper

The position of pulmonary carcinoids within the spectrum of neuroendocrine tumors of the lung and other tissues

Genes, Chromosomes & Cancer
Reinhard UllmannHelmut H Popper

Abstract

Bronchopulmonary carcinoids comprise 25% of all human carcinoids. The World Health Organization divides them into typical (TC) and atypical forms (ATC), distinguished by differences in mitotic counts lower or higher than 2/2 mm(2) and the presence or absence of necrosis. The reproducibility of this classification with respect to the borderline cases with 1-2 mitotic counts/2 mm(2) has been questioned. We have analyzed 15 TCs and 20 ATCs by comparative genomic hybridization. Loss of 11q was the most frequent aberration in ATC (55%), but was observed only twice in TC (13%). Deletions of 3p were seen only in ATC (25%). Meta-analysis of our data and data from 218 neuroendocrine tumors and 50 non-small-cell lung carcinomas obtained from the literature revealed differences between carcinoids and carcinomas. For example, loss of 5q is frequent in lung carcinomas (75%) but is rarely seen in carcinoids (1.4%). Deletions of 11q are less frequent in neuroendocrine lung carcinomas than in ATC. To obtain a more objective survey of the relationship of pulmonary carcinoids to other neuroendocrine tumors and lung carcinomas, we created a hierarchical clustering dendrogram. This statistical approach resulted in a clear separation of carcinoids ...Continue Reading

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Citations

Apr 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lori J WirthBruce E Johnson
Oct 22, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giuseppe PelosiGiuseppe Viale
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chin-Chen PanYann-Jang Chen
Dec 4, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiziana D'AddaCesare Bordi
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Johannes VoortmanGiuseppe Giaccone
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Feb 1, 2011·Expert Opinion on Therapeutic Targets·Mehtap Cakir, Ashley Grossman
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giuseppe PelosiGiuseppe Viale
Oct 27, 2015·Seminars in Diagnostic Pathology·Mark R Wick, Alberto M Marchevsky
Nov 5, 2003·The Journal of Pathology·R UllmannHelmut H Popper
Apr 26, 2014·Genes, Chromosomes & Cancer·Philipp StröbelAlexander Marx
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Sep 16, 2003·Seminars in Thoracic and Cardiovascular Surgery·D Michael McMullan, Douglas E Wood

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