The positive cognitive impact of aerobic fitness is associated with peripheral inflammatory and brain-derived neurotrophic biomarkers in young adults

Physiology & Behavior
Jungyun HwangF Gonzalez-Lima

Abstract

There is ample evidence for supporting the positive impact of aerobic fitness on cognitive function, but little is known about the physiological mechanisms. The objective of this study was to investigate whether the positive cognitive impact of aerobic fitness is associated with inflammatory and neurotrophic peripheral biomarkers in young adults aged 18 to 29years (n=87). For the objective assessment of aerobic fitness, we measured maximal oxygen uptake (VO2max) as a parametric measure of cardiorespiratory capacity. We demonstrated that young adults with the higher levels of VO2max performed better on computerized cognitive tasks assessing sustained attention and working memory. This positive VO2max-cognitive performance association existed independently of confounders (e.g., years of education, intelligence scores) but was significantly dependent on resting peripheral blood levels of inflammatory (C-reactive protein, CRP) and neurotrophic (brain-derived neurotrophic factor, BDNF) biomarkers. Statistical models showed that CRP was a mediator of the effect of VO2max on working memory. Further, BDNF was a moderator of the effect of VO2max on working memory. These mediating and moderating effects occurred in individuals with highe...Continue Reading

Citations

Nov 15, 2018·Memory·Krystle E ZunigaWilliam L Kelemen
May 12, 2019·Medicina·Brandon Rigdon, Paul D Loprinzi
Aug 31, 2018·Frontiers in Psychology·Daniel R WestfallAnna Bugge
Jan 4, 2021·European Journal of Applied Physiology·Pedro B JúdiceLuís B Sardinha
Jul 28, 2020·NeuroImage·Gustavo S P PamplonaCarlos E G Salmon
Apr 4, 2021·International Journal of Environmental Research and Public Health·Lin ChiChenglin Zhou
Jul 16, 2021·Journal of the International Neuropsychological Society : JINS·Ryan M SullivanKrista M Lisdahl
Sep 16, 2021·Journal of Intellectual Disability Research : JIDR·R Cabeza-RuizP T Gómez-Píriz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.