Abstract
There is ample evidence for supporting the positive impact of aerobic fitness on cognitive function, but little is known about the physiological mechanisms. The objective of this study was to investigate whether the positive cognitive impact of aerobic fitness is associated with inflammatory and neurotrophic peripheral biomarkers in young adults aged 18 to 29years (n=87). For the objective assessment of aerobic fitness, we measured maximal oxygen uptake (VO2max) as a parametric measure of cardiorespiratory capacity. We demonstrated that young adults with the higher levels of VO2max performed better on computerized cognitive tasks assessing sustained attention and working memory. This positive VO2max-cognitive performance association existed independently of confounders (e.g., years of education, intelligence scores) but was significantly dependent on resting peripheral blood levels of inflammatory (C-reactive protein, CRP) and neurotrophic (brain-derived neurotrophic factor, BDNF) biomarkers. Statistical models showed that CRP was a mediator of the effect of VO2max on working memory. Further, BDNF was a moderator of the effect of VO2max on working memory. These mediating and moderating effects occurred in individuals with highe...Continue Reading
Citations
Nov 15, 2018·Memory·Krystle E ZunigaWilliam L Kelemen
Nov 27, 2018·Journal of the International Neuropsychological Society : JINS·Natasha E WadeKrista M Lisdahl
Jan 9, 2019·Neurological Research·Michael KingMichelle Ploughman
May 12, 2019·Medicina·Brandon Rigdon, Paul D Loprinzi
May 31, 2018·PloS One·Chia-Kuang TsaiWei-Liang Chen
Aug 31, 2018·Frontiers in Psychology·Daniel R WestfallAnna Bugge
Apr 30, 2019·Frontiers in Psychiatry·Laís TonelloDaniel Boullosa
Sep 29, 2020·Frontiers in Physiology·Olga TarassovaJonna Nilsson
Sep 14, 2018·Journal of Clinical Medicine·Jungyun HwangAmy Shirong Lu
Jul 22, 2018·Scientific Reports·Jungyun Hwang, Amy Shirong Lu
Nov 6, 2018·Physical Therapy·Jessica R WoelfelRichard K Shields
Feb 27, 2020·Brain Sciences·Ryan M SullivanKrista M Lisdahl
Mar 15, 2018·Experimental Brain Research·Jungyun HwangF Gonzalez-Lima
May 7, 2020·Frontiers in Physiology·Catherine FosterRichard G Wise
Jun 11, 2020·Antioxidants·Irene PetracciLaura Bordoni
Dec 2, 2020·PloS One·Natasha E WadeKrista M Lisdahl
Jan 4, 2021·European Journal of Applied Physiology·Pedro B JúdiceLuís B Sardinha
Jul 28, 2020·NeuroImage·Gustavo S P PamplonaCarlos E G Salmon
Jan 12, 2021·Journal of Alzheimer's Disease : JAD·Mehnaz AhmedKrista L Lanctôt
Nov 30, 2020·Pediatric Obesity·Nicole E LoganCharles H Hillman
Apr 4, 2021·International Journal of Environmental Research and Public Health·Lin ChiChenglin Zhou
Jul 16, 2021·Journal of the International Neuropsychological Society : JINS·Ryan M SullivanKrista M Lisdahl
Sep 16, 2021·Journal of Intellectual Disability Research : JIDR·R Cabeza-RuizP T Gómez-Píriz