The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer

Oncotarget
Jianmei WangYanqing Ding

Abstract

DAB2IP has been identified as a tumor suppressor in several cancers but its oncogenic role and transcriptionally regulatory mechanisms in the progression of colorectal carcinoma (CRC) remain unknown. In this study, DAB2IP was down-regulated in CRC tissues and a valuable prognostic marker for survival of CRC patients, especially in the late stage. Moreover, DAB2IP was sufficient to suppress proliferation, epithelial-mesenchymal transition (EMT), invasion and metastasis in CRC. Mechanically, the linear complex of EZH2/HDAC1/Snail contributed to DAB2IP silencing in CRC cells. The study further proved that the positive feedback loop between Snail and DAB2IP existed in CRC cells and DAB2IP was required for Snail-induced aggressive cell behaviors. Finally, DAB2IP correlated negatively with Snail and EZH2 expressions in CRC tissues. Our findings reveal the suppressive role and a novel regulatory mechanism of DAB2IP expression in the progression of CRC. DAB2IP may be a potential, novel therapeutic and prognostic target for clinical CRC patients.

References

Nov 26, 2002·The Journal of Biological Chemistry·Hong ChenJer-Tsong Hsieh
Apr 15, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Carolyn C Compton
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hideaki DoteNobuyoshi Shimizu
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Masaaki YanoNobuyoshi Shimizu
Aug 30, 2008·Mutation Research·Jeffrey A Simon, Carol A Lange
Nov 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Daxing XieJer-Tsong Hsieh
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Daxing XieJer-Tsong Hsieh
Apr 21, 2011·The Journal of Pathology·Xi-Ling ZhuLi Liang
Dec 16, 2011·Journal of Gastroenterology and Hepatology·Xiaojing ZhangYanqing Ding
Jun 15, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michiel SmitsThomas Würdinger
Oct 31, 2013·Current Cancer Drug Targets·Yifan WangBinhua P Zhou

❮ Previous
Next ❯

Citations

Apr 28, 2020·Technology in Cancer Research & Treatment·Yifan DuanFan Meng
Nov 20, 2016·Cell Death and Differentiation·Arianna BellazzoLicio Collavin
Oct 30, 2016·Oncotarget·Anthos ChristofidesVassiliki A Boussiotis
Dec 31, 2016·Oncotarget·Krystal D NolanJennifer S Isaacs
Jan 6, 2018·International Journal of Molecular Sciences·Inamul HaqueSushanta K Banerjee
Jun 30, 2018·International Journal of Molecular Medicine·Xingguang LiuQian Tao
Dec 15, 2015·Oncotarget·Liang LiuDaxing Xie

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Flow Cytometry
ChIP
transfection
co-IP
Confocal microscopy
nuclear translocation
ubiquitination
xenograft
biopsy

Software Mentioned

DP2
BSW
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.