The positive inotropic effect of the aqueous extract of Convallaria keiskei in beating rabbit atria

Life Sciences
Deok Ho ChoiHo Sub Lee

Abstract

The positive inotropic effect of the aqueous extract of Convallaria keiskei (ACK) and the possible mechanisms responsible for this effect were investigated in beating rabbit atria. ACK significantly increased atrial stroke volume, pulse pressure, and cAMP efflux in beating rabbit atria. The effects were not altered by pre-treatment with staurosporine and diltiazem, a non-selective protein kinase inhibitor and an L-type Ca2+ channel blocker, respectively. In addition, ACK markedly increased the K+ concentration in the beating atria-derived perfusate. Convallatoxin, a well-known digitalis-like cardiac glycosidic constituent of ACK, also increased atrial stroke volume and pulse pressure but did not alter the cAMP efflux level. The increases in atrial stroke volume and pulse pressure induced by convallatoxin were not also altered by pre-treatment with diltiazem. These results suggest that the ACK-induced positive inotropic effect in beating rabbit atria may, at least in part, be due to the digitalis-like activity of convallatoxin.

References

Oct 15, 1985·European Journal of Biochemistry·H OzakiN Urakawa
Aug 1, 1967·Chemical & Pharmaceutical Bulletin·M KimuraI Yoshizawa
Jan 1, 1966·Chemical & Pharmaceutical Bulletin·M KimuraI Yoshizawa
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Apr 12, 2000·Circulation·R J LefkowitzW J Koch
Sep 1, 2000·Journal of Molecular and Cellular Cardiology·S R HouserJ Weisser
Jan 5, 2002·Journal of Cardiovascular Electrophysiology·A RakhitC I Berul
May 16, 2002·Circulation·Marvin A Konstam, Douglas L Mann
Aug 1, 2002·Nature Cell Biology·Andrea L Bauman, John D Scott
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Gerd Hasenfuss, Burkert Pieske
Sep 21, 2002·European Journal of Pharmacology·Xun CuiKyung Woo Cho

❮ Previous
Next ❯

Citations

Sep 30, 2014·European Journal of Pharmacology·Elnaz GozalpourJan B Koenderink
Apr 20, 2014·Journal of Ethnopharmacology·Alexander N ShikovMichael Heinrich
Aug 16, 2014·American Journal of Clinical Pathology·Kerry J WelshAmitava Dasgupta
Jun 2, 2018·Journal of Clinical Laboratory Analysis·Amitava Dasgupta, Laverne Bourgeois

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.