PMID: 12753501May 20, 2003Paper

The possibility of B-cell-dependent T-cell development

Scandinavian Journal of Immunology
S KeshavarziM Cascalho

Abstract

The development of T cells is thought to be independent of B cells. However, defects in cell-mediated immunity in individuals with B-cell deficiency suggest the contrary. To test whether B cells affect T-lymphocyte development, we constructed mice with a monoclonal T-cell compartment (MT) and monoclonal B- and T-cell compartments (MBTs). In these mice, the T cells expressed a DO 11.10 transgenic (DO-T) cell receptor restricted to major histocompatibility complex (MHC) class IId. While CD4+ DO-T lymphocytes are rare in transgenic H-2b MT mice, we found that in H-2b MBT mice under the influence of B cells, DO-T lymphocytes mature into large numbers of CD4+ peripheral T cells. H-2b MBT mice have more CD4+ thymocytes than H-2b MT mice. These data are consistent with the view that B cells play some role in thymocyte development.

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Citations

Jun 7, 2006·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Marilia Cascalho, Jeffrey L Platt
Jun 20, 2008·Pediatric Transplantation·Samuel J BalinMarilia Cascalho
Nov 18, 2006·European Journal of Immunology·Christian VettermannHans-Martin Jäck
Jan 30, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Samuel J BalinMarilia Cascalho
Dec 15, 2010·Current Opinion in Organ Transplantation·Jeffrey L PlattMarilia Cascalho
Jan 26, 2005·Pediatric Transplantation·Marilia Cascalho, Jeffrey L Platt
Oct 6, 2005·International Immunology·Lynn Heltemes-HarrisTim Manser
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristina JoãoMarilia Cascalho
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naoki KanayamaHitoshi Ohmori
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mouhammed AbuAttiehMarilia Cascalho
Apr 14, 2019·Human Immunology·Jeffrey L Platt, Marilia Cascalho

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