The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours

Oncotarget
Hiroaki KajiyamaFumitaka Kikkawa

Abstract

The objective of this study was to estimate the frequency of possible occult metastasis through long-term survival analyses in patients with clear cell carcinoma (CCC) who had undergone complete resection. During the period of 1990-2015, 799 patients with stage I-IV CCC were identified in the TOTSG database. Of these, a total of 528 patients without a residual tumor were enrolled in the study and classified into four groups: Group 1: FIGO stage IA-IB (N=104), Group 2: FIGO stage IC1 (N=170), Group 3: FIGO stage IC2/IC3 (N=98), and Group 4: FIGO stage II-III (no residual tumor: N=156). Cumulative incidences of recurrence (CIR) and death (CID) were examined. The median age was 54, ranging from 29-87. The 5-year CIR / CID of each group were as follows: Group 1 (7.3% / 3.8%), Group 2 (14.3% / 10.2%), Group 3 (37.7% / 18.4%), and Group 4 (46.5% / 33.8%), respectively {P<0.0001 (recurrence) /P<0.0001 (death)}. Furthermore, confining analysis to relapsed patients, 1-, 2-, and 3-year CID after recurrence were 41.5, 60.9, and 73.9, respectively. Confining analyses to patients with sufficient information about adjuvant chemotherapy, the 5-year CIR / CID of stage IA-IC1 patients with or without chemotherapy were as follows: recurrence {13...Continue Reading

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Citations

Sep 22, 2019·International Journal of Clinical Oncology·Maya HanataniFumitaka Kikkawa
Jan 7, 2020·International Journal of Cancer. Journal International Du Cancer·Masato YoshiharaFumitaka Kikkawa
Dec 11, 2019·Cancers·Sadaf FarsinejadMarcin Iwanicki
Oct 3, 2019·Journal of Gynecologic Oncology·Kosuke YoshidaFumitaka Kikkawa
Mar 8, 2021·International Journal of Clinical Oncology·Shinichi TateMakio Shozu
May 1, 2021·International Journal of Molecular Sciences·Filipa Lopes-CoelhoJacinta Serpa
Jul 30, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yoshiki IkedaHiroaki Kajiyama

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Methods Mentioned

BETA
surgical resection
biopsies

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