The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review

Functional Neurology
Mariangela SpanoBruno Giometto

Abstract

The hallmark of dementia with Lewy bodies (DLB) is the “Lewy body”, an abnormal aggregation of alpha-synuclein found in some areas of the brain. The brain is the organ/system that is most vulnerable to this oxidative damage, and reactive oxygen species can cause neurodegenerative diseases. Different models of mitochondrial deregulation have been compared in DLB. The results are consistent with the hypothesis that alpha-synuclein affects the mitochondria themselves, increasing their sensitivity or leading to cell death through protective (neurosin) and accelerating (cytochrome c) factors. This systematic review suggests that mitochondria play an important role in neurodegeneration and a crucial role in the formation of Lewy bodies. DLB is a disease characterized by abnormal accumulation of alpha-synuclein that could result in the release of cytochrome c and subsequent activation of the apoptotic cascade.

Citations

Nov 23, 2017·Frontiers in Molecular Neuroscience·Ahmad R ArshadNor Azian Abdul Murad
Feb 28, 2018·Frontiers in Aging Neuroscience·Devesh TewariAtanas G Atanasov
May 1, 2021·International Journal of Molecular Sciences·Laura DobladoMaria Monsalve
Aug 7, 2021·Biomedicines·Dario BrunettiMassimo Zeviani

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