The possible protective effect of N-acetyl-L-cysteine and folic acid in combination against aspartame-induced cerebral cortex neurotoxicity in adult male rats: a light and transmission electron microscopic study

Ultrastructural Pathology
Hala F Abd-EllahNadia M Nasr

Abstract

The purpose of this study is to investigate structural and ultrastructural alterations in the rat's brain cerebral cortex after aspartame (ASP) treatment and to evaluate the possible ameliorating role of N-acetyl-L-cysteine (NAC) and folic acid (FA). Forty adult rats were divided into four equal groups: Group I, received appropriate vehicle only and served as control. Group II, received oral doses of both NAC (600 mg/kg body weight (b.w.)) and FA (12 mg/kg b.w.) daily for 42 days. Group III, received oral doses of ASP (500 mg/kg b.w.) daily for 42 days. Group IV, received both NAC and FA, concurrently with ASP at the same doses, route and period of administration of the previous groups. Histological examination of the cerebral cortex of ASP-treated rats showed severe degenerative changes, especially in the nerve cells. Some of these cells appeared shrunken, irregular in shape, while the others appeared swollen and were surrounded by pericellular halos. Immunohistochemical and morphometric study of ASP-treated group revealed a weak B-cell lymphoma-2 (Bcl-2) immunoexpression in the cytoplasm of many cells, while intense positive immunoreaction for glial fibrillary acidic protein (GFAP) was observed in the cytoplasm and processes ...Continue Reading

References

Jan 1, 1992·Progress in Brain Research·L F EngY L Lee
Jan 1, 1995·Methods in Enzymology·A Meister
Jan 1, 1994·Journal of Neurochemistry·R R RatanJ M Baraban
May 1, 1997·Nutrition Reviews·J E Alpert, M Fava
Jan 1, 1997·Free Radical Biology & Medicine·S M HenningF Liao
Mar 29, 2000·The Journal of Nutrition·S Garattini
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·E C Lai, G M Rubin
Jun 8, 2001·Free Radical Biology & Medicine·R JoshiT Mukherjee
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·M C VerhaarT J Rabelink
May 31, 2002·Pharmacological Reviews·Yossi Gilgun-SherkiDaniel Offen
Aug 7, 2002·The Journal of Nutrition·Susan J DuthieGeorge Grant
Feb 20, 2003·Trends in Neurosciences·Mark P Mattson, Thomas B Shea
Mar 4, 2003·Journal of Cellular and Molecular Medicine·T Wakabayashi
Sep 17, 2004·International Journal of Toxicology·Darryl ArfstenAndrew Bobb
Apr 23, 2005·Glia·Kiran S Panickar, Michael D Norenberg
Feb 24, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A SoliniE Ferrannini
Oct 19, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lidia StruzynskaGrzegorz Sulkowski
Jan 27, 2007·Annals of Neurology·Xiaoyang WangCarina Mallard
Jul 28, 2007·Methods in Molecular Biology·José A Mascorro, John J Bozzola
Aug 9, 2007·European Journal of Clinical Nutrition·P HumphriesH Naudé
Sep 14, 2007·The Cerebellum·Motoki Arakawa, Yoshihisa Ito
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
May 27, 2008·Journal of the International Society of Sports Nutrition·Chad Kerksick, Darryn Willoughby
Jul 9, 2008·BMC Neuroscience·Nadia FerlazzoDaniela Caccamo
Apr 25, 2009·Basic & Clinical Pharmacology & Toxicology·Atish Prakash, Anil Kumar
Mar 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M AbhilashR Harikumaran Nair
Apr 30, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dan FengJing Ma
Aug 9, 2011·Neurotoxicity Research·Omar M E Abdel-SalamJihan Seid Hussein
Apr 5, 2013·Folia Neuropathologica·Karol Rycerz, Jadwiga Elżbieta Jaworska-Adamu
Apr 1, 2014·Brain and Behavior·Reza Bavarsad ShahripourAndrei V Alexandrov
Dec 10, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Semira GonsethJoseph L Wiemels
Aug 28, 2016·Journal of Chemical Neuroanatomy·Adejoke Y OnaolapoPolycarp U Nwoha

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