PMID: 6403852Mar 1, 1983Paper

The possible role of azoreduction in the bacterial mutagenicity of 4-dimethylaminoazobenzene (DAB) and 2 of its analogues (6BT and 5I)

Mutation Research
J AshbyR D Callander

Abstract

The extent to which azoreductive cleavage contributes to the bacterial mutagenicity of 3 azo compounds has been investigated. The compounds studied were the rodent-liver carcinogens 4-dimethylaminoazobenzene (DAB) and 6-dimethylaminophenylazobenzthiazole (6BT), and the reported non-carcinogenic isostere 5-dimethylaminophenylazoindoline (5I). Although each of these compounds is mutagenic to Salmonella when evaluated using a pre-incubation protocol and in the presence of an induced rat-liver S9 mix, the constituent amines (cleavage products) were essentially inactive. It is therefore concluded that the mutagenic response reported for DAB, 6BT and 5I is related to metabolic activation of the intact molecules. In addition, the non-mutagenicity of 4'-phenyl-4-dimethylaminoazobenzene (4PhDAB) suggests that azoreductase activity is low in the Salmonella preincubation assay, at least as conducted in this laboratory. In the case of 4PhDAB, less than 1.4% azoreduction would yield sufficient quantities of the derived amine, 4-aminobiphenyl, for a positive mutagenic response to have been observed.

References

Dec 1, 1970·Food and Cosmetics Toxicology·R Walker
Jan 1, 1980·British Medical Bulletin·J Ashby, J A Styles
Jan 1, 1982·Carcinogenesis·J A RobertsonD B McGregor

❮ Previous
Next ❯

Citations

Feb 8, 2008·Journal of Molecular Modeling·F A PashaHoon Cho
May 28, 1992·Biochemical Pharmacology·A M Stoddart, W G Levine
Nov 1, 1989·Mutation Research·H S Rosenkranz, G Klopman
Sep 1, 1992·Mutation Research·K T Chung, C E Cerniglia
Jan 1, 1986·Journal of Toxicology and Environmental Health·G KrishnaJ Nath
Jan 11, 2012·Journal of Hazardous Materials·Rafael Leite de OliveiraMaria Valnice Boldrin Zanoni
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gisela de Aragão UmbuzeiroLarry D Claxton
Sep 17, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·King-Thom Chung
Jan 1, 1991·Drug Metabolism Reviews·W G Levine
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·C S Lin
Dec 6, 2006·Environmental Science & Technology·Danielle P OliveiraGisela A Umbuzeiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.