The possible role of C5 segment inspiratory interneurons investigated by cross-correlation with phrenic motoneurons in decerebrate cats

Experimental Brain Research
J Duffin, S Iscoe

Abstract

We tested the role of C5 segment inspiratory interneurons in transcribing central respiratory drive to phrenic motoneurons and mediating intersegmental reflexes by cross-correlating the spontaneous activity of 26 interneurons with that of the ipsi -and contralateral C5 phrenic nerves in decerebrate cats. There were 10 interneurons that discharged only during inspiration (phrenic burst) and 16 that discharged tonically with increased firing during inspiration. Of the cross-correlograms for 26 of the interneurons with the ipsilateral phrenic, 20 were flat and 2 had peaks centred about time zero, interpreted as a common activation of the interneurons and motoneurons. The cross-correlograms for 4 other interneurons had troughs centred about time zero, interpreted as a synchronous excitation of the interneurons and inhibition of the motoneurons. Of the cross-correlograms for 23 interneurons with the contralateral phrenic, 22 were flat and 1 had a peak centred about time zero, interpreted as a common activation of the interneuron and motoneurons. Nine of ten cross-correlograms between pairs of interneurons were flat; one had a peak centred about time zero. We conclude that, despite their inspiratory modulated discharge patterns, ther...Continue Reading

Citations

Aug 11, 2000·Respiration Physiology·S Iscoe
Oct 17, 1998·Progress in Neurobiology·S Iscoe
Mar 8, 2011·Respiratory Physiology & Neurobiology·Kun-Ze Lee, David D Fuller
Sep 8, 2010·Experimental Neurology·K QiuD D Fuller
Oct 17, 2008·The Journal of Comparative Neurology·Michael A LanePaul J Reier
Aug 21, 2013·Experimental Neurology·Kun-Ze LeeDavid D Fuller
Jun 12, 2013·Respiratory Physiology & Neurobiology·Anthony F DiMarco, Krzysztof E Kowalski
Dec 25, 2012·Respiratory Physiology & Neurobiology·Anthony F Dimarco, Krzysztof E Kowalski
Sep 2, 2016·Experimental Neurology·Kristiina M HormigoMichael A Lane
Feb 8, 2018·Physiology·Matthew J FogartyGary C Sieck
Apr 3, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vitaliy MarchenkoRobert F Rogers
Jan 2, 2015·Journal of Neurophysiology·M S SandhuD D Fuller
Feb 23, 2020·Expert Review of Respiratory Medicine·Matthew J Fogarty, Gary C Sieck
Feb 6, 2020·Frontiers in Systems Neuroscience·Victoria N JensenSteven A Crone
Oct 13, 2017·Journal of Neurophysiology·Michael George Zaki Ghali
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Jan 7, 2018·Experimental Neurology·Michael D SunshineChet T Moritz

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