PMID: 8583248Oct 1, 1995Paper

The possible role of linac-based stereotactic radiotherapy in the treatment of multifocally and heterochronously recurrent malignant astrocytomas. A case report

Journal of Neuro-oncology
M NaganeY Akine

Abstract

We present a 24-year-old woman with multifocal and heterochronous recurrence of malignant astrocytomas that were consecutively treated by linac-based sterotactic radiotherapy. The patient had previously received multimodalities of treatment for malignant astrocytomas in the right occipital lobe consisting of surgical resection on four occasions, conventional external-beam irradiation, immunological therapy, and systemic chemotherapy. Thereafter she developed relatively small and well-demarcated recurrent lesions in eight different sites, most of which were located in eloquent and deep-seated regions. She underwent ten fractionated linac-based stereotactic radiotherapy courses with a median total dose of 42 Gy, seven fractions of 6 Gy each in 15 days, experiencing neither any adverse effects nor neurologic deterioration. Three out of 10 treated lesions responded well with subsequent reduction in size, and 80% of them did not increase at least for 6 months, although 66.7% of the lesions eventually exhibited enlargement of the enhanced areas, some of which were presumed as radiation necrosis. These clinical results suggest that the fractionated linac-based stereotactic radiotherapy had significant effects on tumor growth inhibitio...Continue Reading

References

Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S S GillM Brada
Oct 1, 1990·The British Journal of Radiology·E S ThomsonD Doughty
Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LoefflerE Alexander
Jul 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerD A Larson
Feb 1, 1987·International Journal of Radiation Oncology, Biology, Physics·V SturmS Kunze
Feb 1, 1985·Neurosurgery·F ColomboA Zanardo
Jun 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G H HartmannW J Lorenz
Sep 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·L Leksell
Aug 15, 1994·Cancer·M C ChamberlainW M Shea
Apr 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K TokuuyeS Shibui
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·E J Hall, D J Brenner

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Citations

Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·K TokuuyeK Nomura

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