The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation

Dermatology : International Journal for Clinical and Investigative Dermatology
H Akamatsu, T Horio

Abstract

The purpose of this study was to investigate the possible role of reactive oxygen species (ROS) generated by neutrophils in mediating acne inflammation. Antibiotics used for the treatment of acne significantly inhibited ROS generated by neutrophils, when compared to other antibiotics. Metronidazole, which is effective in the treatment of acne, markedly inhibited ROS generated by neutrophils. The drug is known to have no significant effect on the growth of Propionibacterium acnes. The proportion of linoleic acid is markedly decreased in acne comedones. Linoleic acid significantly suppressed ROS generated by neutrophils. The ability of neutrophils to produce ROS was significantly increased in patients with acne inflammation. These results seem to reveal the involvement of ROS generated by neutrophils in the disruption of the integrity of the follicular epithelium, which is responsible for inflammatory processes of acne.

Citations

Sep 5, 2001·Journal of Dermatological Science·S InuiS Itami
Oct 13, 2006·Current Opinion in Infectious Diseases·E Ingham
Apr 24, 2008·Pediatric Dermatology·Julie A FennerNikki A Levin
Mar 3, 2009·Biological & Pharmaceutical Bulletin·Yoichi IshitsukaTetsumi Irie
Jan 6, 2010·Indian Journal of Dermatology·Khalid O Abulnaja
May 15, 2001·The Journal of Dermatology·P Y BasakI Kilinc
Apr 24, 2007·Medical Hypotheses·Martin Katzman, Alan C Logan
Aug 22, 2000·The Journal of Investigative Dermatology·W HongcharuR R Anderson
Jul 3, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meital PortugalRon Kohen
Aug 8, 2008·The British Journal of Dermatology·Nermeen S A Abdel FattahE S El Okda
Apr 21, 2012·Cell Biochemistry and Function·İjlal ErturanVahide Baysal Akkaya
Jan 18, 2013·Journal of Clinical Laboratory Analysis·Hani A Al-ShobailiZafar Rasheed
Dec 1, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·G SariciN S Tekin
Nov 24, 2004·Clinics in Dermatology·Mark D Farrar, Eileen Ingham
Apr 15, 2003·The Journal of Dermatology·Mehmet YildirimNamik Delibas
Nov 30, 2006·The Ocular Surface·Lenio S Alvarenga, Mark J Mannis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Mediators of Inflammation
Ozer AricanSezai Sasmaz
Journal of the European Academy of Dermatology and Venereology : JEADV
B AybeyN Onsun
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
J-J LiuY-Z He
© 2022 Meta ULC. All rights reserved