PMID: 6407272Jan 1, 1983Paper

The possible roles of prostaglandins and related compounds in endometrial bleeding. A mini-review

Acta Obstetricia Et Gynecologica Scandinavica. Supplement
E GranströmV Lundström

Abstract

This mini-review summarizes some aspects of hemostatic defects, with particular reference to endometrial bleeding, both the normal menstruation and some bleeding disorders of the uterus. Two cell types are of particularly great interest in the hemostatic mechanism, viz. the platelet and the vascular endothelial cell. We will therefore start with a brief survey of the roles of platelets and vascular endothelium in hemostasis, and the underlying biochemical events will be discussed, particularly the participation of the arachidonate metabolites: the prostaglandins, the thromboxanes and the leukotrienes. This section is then followed by a brief description of some histological findings in the menstruating endometrium; the normal as well as the pathologically bleeding tissue. The possible roles of arachidonate metabolites in these events will be discussed. Several clinical studies have been published, in which various attempts have been made to treat excessive endometrial bleeding with inhibitors of prostaglandin biosynthesis. The findings in these studies are described. The relevance of this approach and its possible effects on other areas of arachidonic acid metabolism will be discussed. Finally, some studies will be summarized i...Continue Reading

Citations

Dec 1, 1987·Prostaglandins·M J PeekR Markham
Jan 1, 1986·Lung·S P Hanley
May 1, 1992·American Journal of Obstetrics and Gynecology·M A van EijkerenJ J Sixma
Mar 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·M Akerlund

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