The possible use of hypoxic preconditioning for the prophylaxis of post-stress depressive episodes.

Neuroscience and Behavioral Physiology
Elena RybnikovaAlexandr Kolchev

Abstract

The protective effects of hypoxic preconditioning on the development of depressive states in rat models were studied. Three episodes of intermittent preconditioning using hypobaric hypoxia (360 mmHg, 2 h) prevented the onset of depressive behavioral reactions, hyperfunction of the hypophyseal-adrenal system, and impairments in its suppression in the dexamethasone test in rats following unavoidable aversive stress in a model of endogenous depression. The anxiolytic and antidepressant actions of hypoxic preconditioning in experiments on rats were no less marked than those of the tetracyclic antidepressant ludiomil. The results obtained here provide evidence that preconditioning with intermittent hypobaric hypoxia increases resistance to psychoemotional stresses, has marked anxiolytic and antidepressant effects, and can be used for the prophylaxis of depressive episodes.

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Citations

Jan 12, 2012·Bulletin of Experimental Biology and Medicine·L M KurtasovaA A Savchenko
Sep 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angela Navarrete-Opazo, Gordon S Mitchell
Nov 4, 2010·Cellular and Molecular Neurobiology·Dona Lee WongRichard Kvetnansky
Aug 14, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·K A Baranova, M Yu Zenko

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