The post-illumination pupil response of melanopsin-expressing intrinsically photosensitive retinal ganglion cells in diabetes

Acta Ophthalmologica
Beatrix FeiglRawlyn Jones


This study investigates the clinical utility of the melanopsin-expressing intrinsically photosensitive retinal ganglion cell (ipRGC) controlled post-illumination pupil response (PIPR) as a novel technique for documenting inner retinal function in patients with Type II diabetes without diabetic retinopathy. The PIPR was measured in seven patients with Type II diabetes, normal retinal nerve fibre thickness and no diabetic retinopathy compared to healthy age-similar controls. A 488- and 610-nm, 7.15-diameter stimulus was presented in Maxwellian view to the right eye and the left consensual pupil light reflex was recorded. The group data for the blue PIPR (488 nm) identified a trend of reduced ipRGC function in patients with diabetes with no retinopathy. The transient pupil constriction was lower on average in the diabetic group. The relationship between duration of diabetes and the blue PIPR amplitude was linear, suggesting that ipRGC function decreases with increasing diabetes duration. This is the first report to show that the ipRGC-controlled PIPR may have clinical applications as a non-invasive technique for determining the progression of inner neuroretinal changes in patients with diabetes before they are ophthalmoscopically ...Continue Reading


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Nov 13, 2001·American Journal of Ophthalmology·L P AielloJ S Wong
Nov 16, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Masahiko SugimotoYukitaka Uji
Jun 27, 2006·Investigative Ophthalmology & Visual Science·Rachel S LiKwok-Fai So
Feb 27, 2007·Vision Research·Paul D R GamlinDennis M Dacey
Aug 31, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Jan van de Kraats, Dirk van Norren
Sep 27, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Aki Kawasaki, Randy H Kardon
Jun 3, 2008·Investigative Ophthalmology & Visual Science·Matthew J GastingerAlistair J Barber
Jun 25, 2009·PloS One·Ludovic S MureHoward M Cooper
Dec 17, 2009·Investigative Ophthalmology & Visual Science·Laxmikanth KankipatiPaul D Gamlin
Apr 9, 2010·Proceedings. Biological Sciences·Sei-ichi TsujimuraKazutomo Yunokuchi
Apr 15, 1987·Applied Optics·J PokornyM Lutze
Jun 19, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Emma L MarkwellAndrew J Zele
Jul 28, 2010·Brain : a Journal of Neurology·Chiara La MorgiaValerio Carelli
Sep 28, 2010·Ophthalmology·Randy KardonAki Kawasaki
Oct 12, 2010·Investigative Ophthalmology & Visual Science·Wendy W HarrisonAnthony J Adams
Nov 16, 2010·Klinische Monatsblätter für Augenheilkunde·B J Wilhelm
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