The post-stimulation undershoot in BOLD fMRI of human brain is not caused by elevated cerebral blood volume

NeuroImage
J FrahmPeter Dechent

Abstract

Functional magnetic resonance imaging (fMRI) based on blood oxygenation level dependent (BOLD) contrast is the most widely used technique for imaging human brain function. However, the dynamic interplay of altered cerebral blood flow (CBF), cerebral blood volume (CBV), and oxidative metabolism (CMRO2) is not yet fully understood. One of the characteristics of the BOLD response is the post-stimulation undershoot, that is increased deoxyhemoglobin, which has been suggested to originate from a delayed recovery of elevated CBV or CMRO2 to baseline. To investigate the CBV contribution to the post-stimulation BOLD undershoot, we performed bolus-tracking experiments using a paramagnetic contrast agent in eight healthy subjects at 3 T. In an initial BOLD experiment without contrast agent, we determined the individual hemodynamic responsiveness. In two separate experiments, we then evaluated the relative CBV (rCBV) during visual stimulation and the post-stimulation undershoot, respectively. The results confirm a pronounced rCBV increase during stimulation (31.4+/-8.6%), but reveal no change in rCBV relative to baseline in the post-stimulation phase (0.7+/-7.2%). This finding renders a CBV contribution to the BOLD MRI undershoot unlikely...Continue Reading

References

Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·J FrahmW Hänicke
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M BlamireR G Shulman
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S OgawaP Glynn
Nov 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J M LevinP F Renshaw
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmA Kleinschmidt
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleR M Weisskoff
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonL R Frank
Dec 5, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R P KennanJ C Gore
May 21, 1999·NeuroImage·R D HogeG B Pike
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J B MandevilleR M Weisskoff
Nov 5, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleB R Rosen
May 29, 2002·NeuroImage·Francisca P LeiteJoseph B Mandeville
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M Van Zijl
Aug 27, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S T FrancisP A Gowland
Jul 9, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hanzhang LuPeter C M Van Zijl
Oct 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ikuhiro KidaFahmeed Hyder
Nov 1, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manus J DonahuePeter C M van Zijl
Dec 21, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tae KimSeong-Gi Kim
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A Scouten, R T Constable

❮ Previous
Next ❯

Citations

Nov 9, 2010·Brain Topography·Solenna BlanchardFabrice Wendling
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Karen J MullingerSusan T Francis
Nov 26, 2009·Journal of Integrative Neuroscience·Peter A Bandettini
Aug 6, 2014·Brain Connectivity·Peter A Bandettini
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahuePeter Jezzard
May 10, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Steffen Norbert KriegerRobert Turner
Sep 18, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahuePeter C M van Zijl
Apr 3, 2009·Annals of the New York Academy of Sciences·Peter A Bandettini
Dec 9, 2010·IEEE Transactions on Medical Imaging·Kangjoo LeeJong Chul Ye
Jan 17, 2012·NeuroImage·Richard B Buxton
Mar 24, 2009·NeuroImage·Jean J Chen, G Bruce Pike
Jan 28, 2012·NeuroImage·Gunnar Krueger, Cristina Granziera
Jan 18, 2012·NeuroImage·Peter C M van ZijlHanzhang Lu
Aug 26, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter DechentJens Frahm
Apr 7, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jun HuaPeter C M van Zijl
Sep 6, 2013·Reports on Progress in Physics·Richard B Buxton
Jul 11, 2018·Frontiers in Molecular Neuroscience·Michelle E WattsCharles Claudianos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Hanzhang LuPeter C M Van Zijl
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Peter DechentJ Frahm
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
R B BuxtonL R Frank
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Manus J DonahuePeter C M Van Zijl
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Essa YacoubNoam Harel
© 2021 Meta ULC. All rights reserved