The postimplantation electrocardiogram predicts clinical response to cardiac resynchronization therapy

Pacing and Clinical Electrophysiology : PACE
Edward CoverstoneTimothy W Smith

Abstract

Biventricular (BiV) pacing for cardiac resynchronization therapy (CRT) is intended to improve left ventricular function by coordinating systolic activity of the septum and free walls. Optimal resynchronization should be manifested by 12-lead electrocardiogram (ECG) patterns consistent with resynchronized activation, a tall (≥4 mm) R wave in V1, and predominant negative deflection in lead I (RV1SI). We investigated whether the presence or absence of RV1SI predicts heart failure outcomes within 1 year of CRT implant. Two independent physicians reviewed the paced ECG of 213 patients post-CRT device implantation with disputes resolved by a third reviewer. The primary end points of all-cause death, unplanned hospitalization, left ventricular assist device implant, or transplant within a 1-year follow-up were blindly adjudicated according to standard definitions. Groups were compared via Kaplan-Meier estimates and Cox proportional hazards models to determine association with event-free survival. Among CRT patients postimplantation, 56 (26.3%) exhibited the RV1SI pattern on ECG. Patients with the RV1SI pattern were significantly less likely to achieve the primary end point as compared to patients without the RV1SI pattern (33.9% vs 52...Continue Reading

References

Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Nov 3, 2007·Pacing and Clinical Electrophysiology : PACE·Michael C GiudiciS Serge Barold
May 7, 2008·Circulation·Eugene S ChungJaime Murillo
Mar 11, 2009·Pacing and Clinical Electrophysiology : PACE·Sylvain PlouxJacques Clementy
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Nov 5, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Maurizio GaspariniAlessio Cappelleri
Nov 26, 2010·Pacing and Clinical Electrophysiology : PACE·Larisa G TereshchenkoRonald D Berger
Feb 18, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Angelo Auricchio, Frits W Prinzen
Nov 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Julia KöbeLars Eckardt
Mar 15, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Joanna BoidolUNKNOWN Triple-Site Versus Standard Cardiac Resynchronisation Trial (TRUST CRT) Investigators
Apr 1, 2014·The New England Journal of Medicine·Ilan GoldenbergArthur J Moss
Aug 27, 2014·Circulation

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Citations

Dec 13, 2019·Current Treatment Options in Cardiovascular Medicine·Amit NoheriaG Joseph Orme
Jan 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Aaron Vigdor, Paco E Bravo

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