The postoperative platelet distribution width is useful for predicting the prognosis in patients with esophageal squamous cell carcinoma

Surgery Today
Tomoyuki MatsunagaYoshiyuki Fujiwara

Abstract

The platelet distribution width (PDW) is reportedly useful as a prognostic indicator for some cancers. However, its prognostic significance in esophageal squamous cell carcinoma (ESCC) is unclear. We enrolled 104 patients with thoracic ESCC, who underwent curative esophagectomy. Receiver operating curve analyses indicated that the optimal cut-off values of pre- and postoperative PDW were 16.9 and 17.0, respectively. The 5-year overall survival (OS) rate was significantly lower in patients with a high-preoperative PDW (≥ 16.9; 52.6%) than in those with a low-preoperative PDW (< 16.9; 61.0% P = 0.045). The 5-year disease-specific survival (DSS) rates were 64.3% in patients with a high-preoperative PDW and 69.3% in those with a low-preoperative PDW (P = 0.13). Regarding the postoperative PDW, the 5-year OS rate was significantly lower in patients with a high-postoperative PDW (≥ 17.0; 35.7%) than in those with a low-postoperative PDW (< 17.0; 66.8% P = 0.0017). The 5-year DSS rates were 52.2% in patients with a high-postoperative PDW and 73.2% in those with a low-postoperative PDW (P = 0.037). Finally, a multivariate analysis revealed that the postoperative PDW but not the preoperative PDW was an independent prognostic factor. The...Continue Reading

References

Nov 1, 1981·Annals of Internal Medicine·S Karpatkin, E Pearlstein
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Jan 22, 2005·Seminars in Dialysis·Burl R Don, George Kaysen
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 10, 2012·Angiogenesis·Jon E PetersonJudah Folkman
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Sep 6, 2014·Platelets·Charalampos SeretisMark Chapman
Apr 22, 2015·The New England Journal of Medicine·Michael A PostowF Stephen Hodi
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fan ZhangJie He
May 8, 2016·International Journal of Clinical Oncology·Noriyuki HiraharaYoshitsugu Tajima
Jul 27, 2017·World Journal of Surgery·Noriyuki HiraharaYasunari Kawabata

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