The postoperative serum interleukin-15 concentration correlates with organ dysfunction and the prognosis of septic patients following emergency gastrointestinal surgery

The Journal of Surgical Research
Akifumi KimuraJunji Yamamoto

Abstract

To clarify the time course of changes in the serum interleukin-15 (IL-15) concentrations in septic patients undergoing emergency surgery for abdominal infection and to investigate whether the serum IL-15 levels correlate with the postoperative clinical course of septic patients. Twenty-four septic patients who had intra-abdominal infection and who underwent an emergency operation were enrolled in this study. The serum IL-15 levels were measured before surgery, and on postoperative d 1 (POD1), POD3, and POD5, and the relationship between the serum IL-15 levels and the postoperative clinical course estimated by the Systemic Inflammatory Response Syndrome (SIRS) criteria, Acute Physiology and Chronic Health Evaluation (APACHE-II) score, the parameters of organ function, and the 30-d mortality were evaluated. The time course of changes of the serum IL-15 levels were significantly different between survivors and non-survivors (P < 0.05, by repeated measures analysis of variance [ANOVA]). There was a statistically significant relationship between the serum IL-15 levels on POD1 or POD3 and the duration of SIRS (R = 0.50, P < 0.05, R = 0.65, P < 0.01, respectively). Furthermore, a significant positive correlation was observed between t...Continue Reading

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Citations

Dec 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yin GuoEdward R Sherwood
Oct 28, 2015·Critical Care : the Official Journal of the Critical Care Forum·Zhengwen XiaoAndrew W Kirkpatrick
Oct 11, 2019·Journal of Gastric Cancer·Ali Guner, Hyoung-Il Kim
Aug 23, 2020·Journal of Clinical Medicine·Natascha SommerMatthias Hecker

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