The postsynaptic scaffold proteins ProSAP1/Shank2 and Homer1 are associated with glutamate receptor complexes at rat retinal synapses

The Journal of Comparative Neurology
Johann Helmut BrandstätterTobias M Boeckers

Abstract

The postsynaptic density (PSD) at glutamatergic synapses is a macromolecular complex of various molecules that organize the different glutamate receptors spatially and link them to their appropriate downstream signaling pathways and to the cytoskeleton. Recently, a new family of multidomain proteins called Shanks or ProSAPs (proline-rich synapse-associated proteins) has been identified. They are suggested to be central adaptor proteins of the PSD of glutamatergic synapses, bridging different types of glutamate receptor complexes. With immunocytochemistry and light and electron microscopy, we examined the cellular, synaptic, and postnatal developmental expression of ProSAP1/Shank2 at the synapses of rat retina. With double-labeling experiments and confocal microscopy, we analyzed the association of ProSAP1/Shank2 with proteins specific for glutamatergic, glycinergic, and gamma-aminobutyric acid (GABA)ergic synapses and with proteins known to be involved in the structural and functional organization of PSDs containing N-methyl-D-aspartate receptors [95-kDa postsynaptic density protein (PSD-95)], group I metabotropic glutamate receptors (Homer1), and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors [glutamate...Continue Reading

References

Sep 15, 1979·The Journal of Comparative Neurology·L J Fisher
Apr 1, 1991·Physiological Reviews·H Wässle, B B Boycott
Sep 22, 1987·The Journal of Comparative Neurology·G M Horsburgh, A J Sefton
Jul 1, 1974·The Journal of Comparative Neurology·J C BlanksR N Lolley
Apr 1, 1968·Archives of Ophthalmology·T A Weidman, T Kuwabara
Oct 22, 1994·The Journal of Comparative Neurology·E HartveitH Wässle
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Jul 1, 1993·The Journal of Comparative Neurology·K M Bachman, G W Balkema
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Jan 14, 1998·Neuron·E B Ziff
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
May 30, 1998·Cell·S E Craven, D S Bredt
Jul 17, 1998·Vision Research·J H BrandstätterH Wässle
May 21, 1999·The European Journal of Neuroscience·P Koulen
Jul 8, 1999·Current Opinion in Neurobiology·J Kirsch
Oct 21, 1999·Biochemical and Biophysical Research Communications·T M BoeckersE D Gundelfinger
Oct 26, 1999·Progress in Retinal and Eye Research·W B Thoreson, P Witkovsky
Oct 26, 1999·Progress in Retinal and Eye Research·M Kalloniatis, G Tomisich
Jun 14, 2000·Current Opinion in Neurobiology·B XiaoP F Worley
Jun 17, 2000·Trends in Cell Biology·C C GarnerR L Huganir
Feb 24, 2001·Die Naturwissenschaften·E D Gundelfinger, S tom Dieck
Mar 17, 2001·Nature Reviews. Neuroscience·R H Scannevin, R L Huganir
Apr 3, 2001·Annual Review of Neuroscience·M Sheng, C Sala
Sep 6, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Lenzi, H von Gersdorff

❮ Previous
Next ❯

Citations

Jul 21, 2007·Visual Neuroscience·Arlene A HiranoNicholas C Brecha
Feb 24, 2007·Genome Biology·Yoko Shiraishi-Yamaguchi, Teiichi Furuichi
Mar 21, 2009·Experimental & Molecular Medicine·Jeong Hun KimKyu Won Kim
Aug 29, 2013·International Journal of Biological Sciences·Stacey S Willard, Shahriar Koochekpour
Oct 27, 2006·FEBS Letters·Masahiko TanakaPeter Koulen
Feb 1, 2011·The Journal of Comparative Neurology·Arlene A HiranoNicholas C Brecha
Sep 5, 2013·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Anuradha Dhingra, Noga Vardi
Apr 22, 2015·Progress in Retinal and Eye Research·Tyler W Stradleigh, Andrew T Ishida
May 18, 2016·Frontiers in Neuroendocrinology·Stephen C GammieBrian E Eisinger
Dec 31, 2016·The Journal of Comparative Neurology·Anna FasoliAndrew T Ishida
Mar 25, 2017·Histochemistry and Cell Biology·J ZimmermannM Raab
Aug 25, 2005·Experimental Biology and Medicine·R Scott DuncanPeter Koulen
Sep 25, 2018·Anatomia, histologia, embryologia·Artur PałaszJohn J Worthington

❮ Previous
Next ❯