The potent depolarizing action of palytoxin isolated from Palythoa tubercurosa on the isolated spinal cord of the frog

British Journal of Pharmacology
Y Kudo, S Shibata

Abstract

1. The effects of palytoxin (PTX) isolated from Palythoa tubercurosa were tested on the isolated intra-arterially perfused spinal cord of the frog. The resting and evoked potentials were recorded by means of a sucrose-gap technique. 2. PTX caused a marked depolarization of both ventral and dorsal roots. The minimum effective concentration was extremely low, approximately 10(-11) M. During the depolarization the evoked ventral and dorsal root potentials were markedly reduced in amplitude. The ventral root reflex was first augmented and then decreased. 3. The depolarization caused by PTX was markedly reduced when the preparation was perfused with NaCl-deficient medium. However, tetrodotoxin (10(-7) M) only slightly inhibited the depolarization. 4. In a high Ca2+ medium (3.6 mM), the time required to reach the maximum depolarization evoked by PTX was significantly prolonged. In contrast, in a low Ca2+ medium (0.9 mM), PTX caused a marked depolarization soon after application. In a Ca2+-free, Mg2+ (9.0 mM) medium, PTX caused rhythmic oscillatory potentials in both ventral and dorsal roots. 5. The potency of N-acetyl PTX was one hundredth that of the parent compound. 6. It is suggested that PTX may interfere with the stabilizing act...Continue Reading

References

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Citations

Jun 1, 1992·Journal of Applied Toxicology : JAT·C P RobinsonM E Bondura
Jul 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·E Habermann
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·N A Castle, G R Strichartz
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H OzakiN Urakawa
Mar 26, 2003·European Journal of Pharmacology·Eiki SatohMasakazu Nishimura
Aug 21, 2012·Chemical Research in Toxicology·Giorgia Del FaveroPaola Lorenzon
Oct 15, 1985·European Journal of Biochemistry·H OzakiN Urakawa
Jun 28, 2016·Toxicon : Official Journal of the International Society on Toxinology·Valentina BrovedaniMarco Pelin
Mar 7, 2007·Organic & Biomolecular Chemistry·Toshiyasu InuzukaDaisuke Uemura
Mar 21, 2006·Journal of Neuroscience Research·Carmen ValeLuis M Botana
Sep 1, 1988·British Journal of Pharmacology·H KarakiS Shibata
Oct 12, 2010·Toxicon : Official Journal of the International Society on Toxinology·Gian Paolo Rossini, Albertino Bigiani

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