The potential anti-xanthoma and anti-atherosclerotic effects of proton pump inhibitors

Journal of Clinical Pharmacy and Therapeutics
M R Namazi, M Sharifian

Abstract

Xanthoma and atherosclerosis are similar in having infiltrations of macrophages that have transformed into foam cells. The oxidized low-density lipoprotein (LDL) promotes adhesion of monocytes to endothelial cells by inducing expression of adhesion molecules on vascular endothelial cells. Macrophages transform into foam cells by incorporating oxidized LDL using several kinds of scavenger receptors. Very recently, it has been shown that LDL oxidation occurs within lysosomes in macrophages in atherosclerotic lesions and the increase of intra-lysosomal PH can prevent LDL oxidation. Given that proton pump inhibitors can decrease the intra-lysosomal acidicty through inhibition of the lysosomal membrane H+/K+ATPase, theses agents could afford protection against atherosclerosis and xanthoma formation.

References

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Citations

May 18, 2010·Archives of Medical Research·Mohammad Reza Namazi, Farideh Jowkar
Jul 7, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alice Capogrosso SansoneMarco Tuccori
Apr 14, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Tiffany Siang Ying FooGareth Jevon

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