The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure

The Proceedings of the Nutrition Society
C LogueA M Gallagher

Abstract

Low-calorie sweeteners (LCS) are commonly used as sugar substitutes in the diet to provide a desired sweet taste without increased energy intake. The number of LCS available on the market has increased considerably over the years and despite extensive evaluation of their safety prior to approval, debate continues around the effects of consumption on health. In Europe, Member States are obligated to monitor exposure to LCS and methods currently used tend to rely on self-reported dietary intake data alongside LCS concentrations in products. However, the acquisition of accurate data can be costly in terms of resources and time and are inherently imprecise. Although LCS are intensely sweet, they are chemically diverse and a limitation of many studies investigating the health effects of consumption is that they often fail to discern intakes of individual LCS. An approach which objectively assesses intakes of individual LCS would therefore allow robust investigations of their possible effects on health. Biomarker approaches have been utilised for the objective investigation of intakes of a range of dietary components and the feasibility of any such approach depends upon its validity as well as its applicability within the target popu...Continue Reading

References

Apr 1, 1977·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L M BallR T Williams
Jul 1, 1990·Food Additives and Contaminants·A G Renwick
Jan 1, 1991·Annals of Nutrition & Metabolism·S A Bingham
Mar 17, 1990·BMJ : British Medical Journal·M B LivingstoneR G Whitehead
Jan 1, 1986·Critical Reviews in Toxicology·B A BoppJ W Kesterson
Oct 1, 1972·The Biochemical Journal·A G Renwick, R T Williams
Aug 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T W SweatmanC D Burgess
Nov 1, 1995·Food Additives and Contaminants·M C Toledo, S H Ioshi
Mar 21, 1998·Journal of the American Dietetic Association
Nov 24, 1999·Food Additives and Contaminants·L A WilsonV L Dumsday
Dec 22, 1999·Regulatory Toxicology and Pharmacology : RTP·J L Herrman, M Younes
Jul 7, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H C Grice, L A Goldsmith
Jul 7, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A RobertsD J Snodin
Jun 9, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Garnier-SagneP Verger
Aug 25, 2001·The British Journal of Nutrition·H CrewsG Williamson
Aug 16, 2002·Regulatory Toxicology and Pharmacology : RTP·Harriett H ButchkoFriedrich K Trefz
Mar 4, 2003·The Journal of Nutrition·Nancy Potischman, Jo L Freudenheim
Mar 4, 2003·The Journal of Nutrition·M Barbara E Livingstone, Alison E Black
Mar 4, 2003·The Journal of Nutrition·Sheila A Bingham
Mar 14, 2003·Public Health Nutrition·Victor KipnisRaymond J Carroll
Mar 18, 2003·Public Health Nutrition·Sheila A Bingham
Jan 17, 2004·Food Additives and Contaminants·L Serra-MajemA G Renwick
Mar 17, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D ArcellaC Leclercq
Apr 20, 2004·Toxicology and Applied Pharmacology·A G RenwickE J Walter
Sep 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R Weihrauch, V Diehl
Nov 26, 2004·Risk Analysis : an Official Publication of the Society for Risk Analysis·Mark C AndersenKenneth Boykin
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Natasa TasevskaSheila A Bingham
Mar 21, 2006·Food Additives and Contaminants·Andrew G Renwick
Mar 30, 2006·Journal of Agricultural and Food Chemistry·Jan M C GeunsSuzanne Toppet
Feb 15, 2007·European Journal of Clinical Nutrition·F Bellisle, A Drewnowski
Mar 3, 2007·American Journal of Public Health·Lenny R VartanianKelly D Brownell
Jun 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A G Renwick
Jun 17, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A WheelerD A Mandarino
Dec 6, 2008·The American Journal of Clinical Nutrition·Richard D Mattes, Barry M Popkin
Apr 10, 2009·Human Genetics·Mazda JenabSheila A Bingham
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·C M LinoS M Cardoso
Dec 24, 2010·The American Journal of Clinical Nutrition·Aifric O'SullivanLorraine Brennan
Jul 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hans VerhagenAlessandro Chiodini
Oct 26, 2011·International Journal of Food Sciences and Nutrition·Soma Ghosh, M L Sudha

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Citations

Apr 27, 2019·The Proceedings of the Nutrition Society·Alison M Gallagher, Caomhán Logue
Jul 13, 2018·Genes & Nutrition·Joseph A RothwellAugustin Scalbert
Jan 10, 2017·Nutrients·Mary TierneyKristina Pentieva
Jan 6, 2021·Environment International·Maryam Zare JeddiRobert Pasanen-Kase

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