Abstract
Although the disease-modifying anti-rheumatic drugs (DMARD) have been widely used in clinics, rheumatoid arthritis (RA) is not completely curable so far. Hence, to seek new drugs for the treatment of RA has become a pursuing goal of rheumatologists and orthopedic surgeons. Since the major pathological characteristic of RA is inflammation, the exploration of anti-inflammatory drugs has become a hotspot. Moreover, the anti-inflammatory and anti-nociceptive functions of nicotinic acetylcholine receptors as well as the related mechanisms have been recently discovered. Based on the above-mentioned, it is promising that the nicotinic acetylcholine receptor agonists will be applied for the treatment of RA. Following in vitro, in vivo experiments as well as clinical trials will even strengthen this viewpoint and more RA patients will benefit from the application of such agents.
References
Sep 1, 1986·Neuropharmacology·M D AcetoB R Martin
May 10, 1995·Annals of the New York Academy of Sciences·J LindstromY Li
Jul 7, 2000·Brain Research·R S BitnerM W Decker
Oct 25, 2000·Neuropharmacology·M I DamajB R Martin
Dec 20, 2002·Nature·Kevin J Tracey
Jan 1, 2003·Nature·Hong WangKevin J Tracey
Jul 19, 2005·Nature Immunology·Wouter J de JongeGuy E Boeckxstaens
Sep 14, 2006·Clinical and Experimental Immunology·H YoshikawaN Suzuki
Feb 3, 2007·The Journal of Clinical Investigation·Kevin J Tracey
Apr 7, 2007·Shock·Ida A J GiebelenTom van der Poll
May 16, 2007·British Journal of Pharmacology·W J de Jonge, L Ulloa
Jul 11, 2007·Shock·Ida A J GiebelenTom van der Poll
Oct 9, 2007·Gastroenterology·Frans O TheWouter J de Jonge
Apr 19, 2008·BMC Musculoskeletal Disorders·Alberto Alonso-RuizAntonio Quintana
Apr 19, 2008·The Journal of Pain : Official Journal of the American Pain Society·Stephen J MedhurstIain P Chessell
Nov 1, 2008·Arthritis and Rheumatism·Jean-Marc WaldburgerGary S Firestein
Dec 26, 2008·Clinical Therapeutics·Elias ZintzarasHaralampos M Moutsopoulos
Jan 1, 2009·Arthritis and Rheumatism·Marjolein A van MaanenPaul P Tak
Feb 11, 2009·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Praveen Rao, Edward E Knaus
Feb 25, 2009·Expert Opinion on Pharmacotherapy·Howard BirnbaumMary Cifaldi
Apr 2, 2009·Nature Reviews. Rheumatology·Marjolein A van MaanenPaul P Tak
Apr 15, 2009·Current Opinion in Rheumatology·Solbritt Rantapää-Dahlqvist
May 1, 2009·Arthritis and Rheumatism·Marjolein A van MaanenPaul P Tak
Jul 28, 2009·Scandinavian Journal of Immunology·M WestmanJ Lampa
Citations
Jun 28, 2012·Fitoterapia·Huaying FanQinggang Meng
Jan 1, 2015·Ayu·Raxit P Rachchh, Varsha J Galani
Mar 31, 2015·Scientific Reports·Yanqiong ZhangShao Li
Aug 5, 2019·Pharmacological Reports : PR·Abdalla M WednMahmoud M El-Mas
Jan 30, 2020·Pharmacological Reports : PR·Abdalla M WednMahmoud M El-Mas
Jun 15, 2021·Inflammopharmacology·Khalil HajiasgharzadehBehzad Baradaran