The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells

The Journal of Nutritional Biochemistry
Dongxia HouXiaohong Jiang

Abstract

MicroRNAs have become the spotlight of the biological community for more than a decade, but we are only now beginning to understand their functions. The detection of stably expressed endogenous microRNAs in human blood suggests that these circulating miRNAs can mediate intercellular communication. Our previous study reported the surprising finding that exogenous rice MIR168a could regulate liver low-density lipoprotein receptor adapter protein 1 (LDLRAP1) gene expression in mice. Here, we show that plant MIR156a, which is abundantly expressed in dietary green veggies, also stably presents in healthy human serum. Compared with age-matched individuals, decreased levels of MIR156a are observed both in serum and blood vessel of cardiovascular disease (CVD) patients. In vitro studies demonstrate that MIR156a can directly target the junction adhesion molecule-A (JAM-A), which is up-regulated in atherosclerotic lesions from CVD patients. Functional studies show that ectopic expression of MIR156a in human aortic endothelial cells reduces inflammatory cytokine-induced monocytes adhesion by suppressing JAM-A. These findings offer a novel vasoprotective molecular mechanism of green veggies through plant microRNAs.

Citations

May 24, 2019·Advances in Nutrition·Lin ZhangYong-Liang Zhang
Aug 28, 2019·Communications Biology·Katia AquilanoDaniele Lettieri-Barbato
Aug 31, 2020·Advances in Nutrition·Abdul Fatah A SamadMuhammad Sajad
Nov 27, 2018·RNA Biology· SanchitaPrabodh Kumar Trivedi
Jan 9, 2020·Cell & Bioscience·Bernardetta LeddaMariangela Miele
Jul 2, 2019·Experimental and Therapeutic Medicine·Marina PotestàCarla Montesano
Jul 13, 2018·International Journal of Molecular Sciences·Wei WangFafu Shen
Jun 6, 2019·American Journal of Physiology. Cell Physiology·Meng LiYong-Liang Zhang
Jan 20, 2021·Cancer Treatment and Research Communications·Amany I AlqosaibiHussein Sabit
Jan 12, 2020·Communications Biology·Katia AquilanoDaniele Lettieri-Barbato
Mar 2, 2021·Frontiers in Pharmacology·Antonella MinutoloCarla Montesano
Mar 12, 2021·The Journal of Nutritional Biochemistry·Juncheng LiuXinchun Shen
Apr 30, 2021·Saudi Journal of Biological Sciences·Bader Alshehri
May 4, 2021·Current Rheumatology Reports·Mohd SaquibSagarika Biswas
May 21, 2021·Frontiers in Genetics·Dan LiKai He
Nov 24, 2021·Journal of Agricultural and Food Chemistry·Wen-Jing ZhuGang Zhao

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