The potential benefits of BIM in the further pursuit of biomarker discovery in cancer therapeutics

Cancer Discovery
Takeshi Yoshida, Eric B Haura

Abstract

In this issue of Cancer Discovery, Faber and colleagues demonstrate that the basal expression of BIM is positively correlated with the amount of apoptosis induced by the corresponding tyrosine kinase inhibitor treatment within the same subtype of several oncogene-addicted cancer cell types. Their results suggest that pre-treatment assessment of BIM levels can identify patients who would benefit from molecularly targeted therapies even after biomarker-based patient selection.

References

Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GiacconeDavid H Johnson
Oct 25, 2008·The Journal of Clinical Investigation·Mark S CraggClare L Scott
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Oct 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anthony C FaberJeffrey A Engelman
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Dec 7, 2011·Cancer Discovery·Anthony C FaberJeffrey A Engelman

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