The Potential Effect of Epidural Anesthesia on Mesenteric Injury after Supraceliac Aortic Clamping in a Rabbit Model

Annals of Vascular Surgery
Rasit OnogluAli Sarigul

Abstract

Epidural anesthesia is known to increase blood flow by producing vasodilatation on mesenteric circulation. In this experimental study, we aim to examine the effect of epidural anesthesia on mesenteric ischemic-reperfusion (IR) injury induced by supracoeliac aortic occlusion in a rabbit model. Twenty-eight male white New Zealand rabbits were assigned into 4 separate groups, with 7 rabbits in each group: group I, control group; group II, IR-only group; group III, IR plus epidural anesthesia group; group IV, epidural anesthesia-only group. IR model was produced by clamping supraceliac aorta with an atraumatic vascular clamp for 60 min, followed by reperfusion for 120 min. An epidural catheter was placed via Th12-L1 intervertebral space by using open technique before aortic clamping in those assigned to epidural anesthesia. IR injury was assessed using blood markers interleukin-6 and IMA and tissue markers superoxide dismutase and malondialdehyde. Also histopathological examination was performed to evaluate the degree of injury. All biochemical markers in group II were significantly elevated in comparison with the other 3 groups (p < 0.05). This was paralleled by a more severe histopathological injury in IR- only group (group II). ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
May 1, 1993·The Journal of Surgical Research·K KoikeA Banerjee
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J R RequenaS R Thorpe
Jun 1, 1997·The Journal of Surgical Research·Y M YaoG Schlag
Jul 18, 2002·The Journal of Surgical Research·Anthony StallionAlan D Levine
Oct 9, 2002·Journal of Vascular Surgery·Sasan NajibiAlan B Lumsden
Oct 16, 2004·Digestive Diseases and Sciences·Ismail Hameed MallickAlexander M Seifalian
Jun 25, 2005·Anesthesia and Analgesia·Shizuko KosugiJunzo Takeda
Apr 25, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Abdulkadir GunduzMurat Topbas
Aug 29, 2009·Vascular and Endovascular Surgery·Achilleas NtinasThomas Gerasimidis
Dec 24, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Zerrin Defne DundarSadik Girisgin
Feb 17, 2015·World Journal of Critical Care Medicine·Antonio SiniscalchiStefano Faenza

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