The potential for monocyte-mediated immunotherapy during infection and malignancy. Part I: apoptosis induction and cytotoxic mechanisms

Leukemia & Lymphoma
M A WilliamsS M Kelsey


The mononuclear phagocyte system consists of peripheral blood monocytes and tissue macrophages that collectively play a major role in host immunity. Far from existing solely as phagocytic scavengers of cell debris and foreign matter, monocytes are highly active and responsive to inflammatory and immunological signals that activate their microbicidal and tumoricidal functions. Cytokines that are secreted as an integral component of the innate immune response such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and -IFN may directly activate the functions of the monocyte system. A key mediator of the effector functions of monocytes is tumour necrosis factor (TNF) which transduces its signals upon binding to specific transmembrane receptors. TNF is highly cytotoxic to micro-organisms and susceptible malignant cells and in most cases delivers its cytotoxic signal to tumour cells by highly regulated mechanisms of programmed cell death or apoptosis. We believe that the numerous functions of the monocyte system may be harnessed for therapeutic gain both in the context of microbiological infection and malignant disease. In this review, the mechanisms by which secreted and monocyte cell-membrane-associated TNF induce apopto...Continue Reading


Sep 9, 1991·International Journal of Cancer. Journal International Du Cancer·S BernasconiA Mantovani
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J M ZarlingG J Todaro
Dec 1, 1995·Journal of Leukocyte Biology·J E Albina
Mar 10, 1995·Science·S Nagata, P Golstein
Jul 14, 1995·The Journal of Biological Chemistry·D R BeidlerV M Dixit
Oct 1, 1995·Immunology Today·G WeissD Fuchs
May 1, 1993·Journal of Leukocyte Biology·S N BelenkyI Rubinstein
Mar 1, 1995·Trends in Genetics : TIG·S J Korsmeyer
Jun 9, 1995·International Journal of Cancer. Journal International Du Cancer·W WaltherD Pfeil
Jan 1, 1995·Journal of Leukocyte Biology·M K SquierJ J Cohen
Sep 10, 1993·Cell·L A TartagliaD V Goeddel
May 28, 1993·Biochemical and Biophysical Research Communications·N Sakai, S Milstien
Jan 1, 1996·Genes & Development·E White
Dec 1, 1995·European Journal of Immunology·A AnelA M Schmitt-Verhulst
Apr 1, 1996·The Journal of Trauma·A AyalaI H Chaudry
Jan 1, 1996·Immunological Investigations·H D DongT Taguchi

❮ Previous
Next ❯


Jun 16, 2004·International Journal of Cancer. Journal International Du Cancer·Masaki IrieGotaro Toda
Mar 10, 2009·Toxicology and Applied Pharmacology·Navneet K DhillonAmy O'Brien-Ladner
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Maria LiljeforsJan-Erik Frödin
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·M KouwenhovenH Link
May 9, 2002·American Journal of Physiology. Renal Physiology·Brenda S ChanVictor L Schuster
Jun 2, 2018·Cancer Immunology, Immunotherapy : CII·Jun YinJohn O Richards

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis