The potential impact and optimal cut-points of using glycated haemoglobin, HbA1c, to detect people with impaired glucose regulation in a UK multi-ethnic cohort

Diabetes Research and Clinical Practice
Samiul A MostafaMelanie J Davies

Abstract

Recommended diagnostic cut-points to detect impaired glucose regulation (IGR, also termed prediabetes: impaired fasting glucose and/or impaired glucose tolerance based on WHO 1999 criteria) are HbA1c 6.0-6.4% and 5.7-6.4% from an International Expert Committee and American Diabetes Association, respectively. We investigated the impact on prevalence/phenotype from using these criteria compared to IGR detected on oral glucose tolerance testing (OGTT) and determined optimal HbA1c cut-points for IGR in a multi-ethnic cohort. Analysis of 8696 participants in the LEADER study of primary care individuals aged 40-75 years without diabetes, in Leicestershire (UK) who underwent OGTT and had HbA1c measured. Use of OGTT detected less people with IGR (n=1407, 16.2%) compared to HbA1c 6.0-6.4% (n=1610, 18.5%) and HbA1c 5.7-6.4%(n=3904, 44.9%), a 1.1- and 2.8-fold increase in prevalence, respectively. There were 930 (10.7%) and 534 (6.1%) people with IGR on OGTT not detected using HbA1c 6.0-6.4% and 5.7-6.4%, respectively. From ROC curve analysis, the optimal cut-point for detecting IGR in white Europeans was HbA1c>or=5.8%, sensitivity/specificity 61.5%/67.9%, but in south Asians HbA1c>or=6.0%, sensitivity/specificity 63.8%/69.4%. Recommended...Continue Reading

References

May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jan 30, 2004·Diabetes Care·Stephen ColagiuriUNKNOWN AusDiab
May 31, 2007·Diabetes Care·William H HermanUNKNOWN Diabetes Prevention Program Research Group
May 8, 2008·The Journal of Clinical Endocrinology and Metabolism·Christopher D SaudekMayer B Davidson
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Oct 8, 2009·Diabetes Care·Esther van 't RietJacqueline M Dekker
Nov 12, 2009·Diabetes Care·Viswanathan MohanK M Venkat Narayan
Jan 14, 2010·Diabetes Care·Zhong X LuJonathan E Shaw

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Citations

Dec 4, 2012·Clinical and Experimental Pharmacology & Physiology·Ting-Ting DuXue-Feng Yu
Apr 11, 2014·Metabolic Syndrome and Related Disorders·Naval K Vikram, Ishwarlal Jialal
Jul 12, 2011·Diabetes Research and Clinical Practice·Soraya SoulimaneBeverley Balkau
Feb 2, 2011·The Medical Clinics of North America·Jonathan Shaw
Feb 16, 2012·Journal of Internal Medicine·M J L HareP Z Zimmet
Dec 18, 2014·American Journal of Epidemiology·Gregory A NicholsUNKNOWN SUPREME-DM Study Group
Jun 13, 2012·Diabetes Care·María José PicónFrancisco J Tinahones
Jun 16, 2012·Diabetes Care·Samiul A MostafaKamlesh Khunti
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Martha K McClintockLinda Waite
May 18, 2016·Journal of Diabetes Investigation·Yujia LiuGuixia Wang
Dec 1, 2012·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Priscilla W PowellClarissa S Holmes
Nov 29, 2016·International Journal of Geriatric Psychiatry·Eva GrahamNorbert Schmitz
Mar 10, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Benjamin J GrayUNKNOWN Prosiect Sir Gâr Group
May 7, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Mick Leach
Nov 16, 2019·Cardiovascular Diabetology·Enric SánchezUNKNOWN ILERVAS project collaborators
Nov 27, 2019·European Journal of Preventive Cardiology·Eberhard StandlOliver Schnell
Jul 10, 2012·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·S A MostafaM J Davies
Jul 1, 2015·Expert Review of Endocrinology & Metabolism·Vanita R Aroda, Asqual Getaneh
Sep 3, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Junyi QianYao Wang

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