PMID: 11604082Oct 18, 2001Paper

The potential impact of bystander effects on radiation risks in a Mars mission

Radiation Research
D J Brenner, C D Elliston

Abstract

Densely ionizing (high-LET) galactic cosmic rays (GCR) contribute a significant component of the radiation risk in free space. Over a period of a few months-sufficient for the early stages of radiation carcinogenesis to occur-a significant proportion of cell nuclei will not be traversed. There is convincing evidence, at least in vitro, that irradiated cells can send out signals that can result in damage to nearby unirradiated cells. This observation can hold even when the unirradiated cells have been exposed to low doses of low-LET radiation. We discuss here a quantitative model based on the a formalism, an approach that incorporates radiobiological damage both from a bystander response to signals emitted by irradiated cells, and also from direct traversal of high-LET radiations through cell nuclei. The model produces results that are consistent with those of a series of studies of the bystander phenomenon using a high-LET microbeam, with the end point of in vitro oncogenic transformation. According to this picture, for exposure to high-LET particles such as galactic cosmic rays other than protons, the bystander effect is significant primarily at low fluences, i.e., exposures where there are significant numbers of untraversed c...Continue Reading

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Citations

Jun 14, 2002·Experimental Hematology·Nicholas Dainiak
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Paul J KeallRupert K Schmidt-Ullrich
Apr 22, 2009·International Journal of Radiation Biology·Kathryn D Held
Mar 16, 2007·International Journal of Radiation Biology·Bobby E Leonard
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F BallariniM Zankl
Sep 24, 2009·Radiation Research·Birger DieriksPatrick Van Oostveldt
Dec 21, 2011·Cancer Letters·Edouard I AzzamDebkumar Pain
Apr 20, 2016·Radiation Research·Polly Y ChangEleanor A Blakely
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Bobby E Leonard
May 17, 2019·Environmental Science and Pollution Research International·Yongjun YeYongming Zhong
May 6, 2009·Medicine, Conflict, and Survival·Chris BusbyInge Schmitz-Feuerhake
Mar 25, 2010·Human & Experimental Toxicology·Zbigniew Jaworowski
May 26, 2005·European Journal of Pediatrics·Lauren E GruberCathleen A Carter
Jun 24, 2015·Environmental Geochemistry and Health·Joana MadureiraAlcides Pereira
Sep 5, 2009·Environmental Monitoring and Assessment·Hoda I El-ReefyHussein M Badran
Sep 6, 2011·Environmental Monitoring and Assessment·Muhammad AliHameed Ahmed Khan
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Jan 29, 2014·Environmental Monitoring and Assessment·Debajyoti BarooahSarat Phukan
Jul 18, 2014·Fukushima Journal of Medical Science·Makoto MiyazakiTetsuo Ishikawa
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Dec 31, 2005·Radiation Protection Dosimetry·Bobby E Leonard
May 16, 2009·Journal of Radiation Research·Marco Durante

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