The potential impact of selective donor deferrals based on estimated blood volume on vasovagal reactions and donor deferral rates.

Transfusion
Jorge A RiosNHLBI Retrovirus Epidemiology Donor Study-II

Abstract

Whole blood donation in the United States is restricted in volume to 10.5 mL/kg or less in an effort to prevent hypovolemic reactions, but still may exceed more than 15% of a donor's estimated blood volume (EBV). We analyzed the association of EBV with prefaint and systemic vasovagal reactions (SVRs) among whole blood donors and the potential impact of an EBV-based deferral policy. Independent predictors for prefaint reactions and SVRs were assessed by multivariate logistic regression analysis on 591,177 unique donors participating in the Retrovirus Epidemiology Donor Study-II study. Young age (16 years old odds ratio [OR], 3.70; 95% confidence interval [CI], 2.78-4.94), low EBV (<3.5 L OR, 3.30; 95% CI, 2.57-4.23), and first-time donation status (OR, 2.33; 95% CI, 2.03-2.67) were the strongest predictors for SVRs, with similar trends seen for prefaint reactions. Sex, height, race, blood center, and donation site were weakly associated predictors. A total of 5.6% of all donors had an EBV of less than 3.5 L and experienced 12.5% of all prefaint reactions and 14.5% of SVRs. The highest reaction rates were seen in donors less than 23 years old with an EBV of less than 3.5 L who comprised 2.7% of all donors, who were mostly female ...Continue Reading

References

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Jan 30, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Christopher R FranceBlaine Ditto
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Citations

Jul 4, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Barbara M MasserDeborah J Terry
Jan 11, 2012·Public Health Nutrition·Edward L MurphyUNKNOWN NHLBI Retrovirus Epidemiology Donor Study II
Sep 8, 2012·Current Opinion in Hematology·Anne F Eder
Aug 19, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nataša VavicMaria Marinozzi
Aug 30, 2011·Transfusion Medicine Reviews·Anne F Eder
Oct 12, 2011·Transfusion·Bruce H Newman, Barry A Siegfried
Nov 15, 2011·Transfusion·Thelma T GonçalezUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component
Jun 21, 2011·Transfusion·Brian CusterUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II)
Jul 30, 2010·Transfusion·Anne F Eder, Jay E Menitove
Sep 9, 2010·Journal of Clinical Apheresis·Anne Eder
Jun 10, 2015·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·G FolléaUNKNOWN European Blood Alliance
Jan 20, 2018·Journal of Risk Research·Kumanan WilsonJennifer Keelan
Oct 28, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Suchet SachdevNeelam Marwaha

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