The potential impact of using glycated haemoglobin as the preferred diagnostic tool for detecting Type 2 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
S A MostafaKamlesh Khunti

Abstract

There are calls to simplify the diagnosis of Type 2 diabetes mellitus (T2DM) to reduce the burden of undiagnosed disease. Glycated haemoglobin (HbA(1c)) is therefore being considered as a preferred diagnostic tool to replace the need for an oral glucose tolerance test (OGTT), considered by many as cumbersome and inconvenient. The aim of this study was to examine the potential impact of the preferred use of HbA(1c) as a diagnostic tool on the prevalence and phenotype of T2DM. Analysis of the Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) cohort for previously undiagnosed individuals between 40 and 75 years of age who had OGTT, repeated if within the diabetes range, and HbA(1c) results. We compared the prevalence and phenotype of subjects with T2DM based on either HbA(1c)> or =6.5% or OGTT using 1999 World Health Organization criteria. From the total population of 8696, we detected 291 (3.3%) with T2DM from using an OGTT, and 502 (5.8%) had HbA(1c)> or =6.5%. Of those diagnosed with T2DM by OGTT, 93 (1.2%) had HbA(1c) <6.5% and therefore would not have been classified as having T2DM using proposed criteria. Using HbA(1c) criteria resulted in 304 (3.5%) additional cases of T2DM, approximately doubling the prevalence. ...Continue Reading

References

Oct 7, 2000·Diabetes Care·M M EngelgauW H Herman
Dec 7, 2000·Diabetes Research and Clinical Practice·C ItoH Harada
Aug 21, 2002·Annals of Internal Medicine·R Graham BarrDaniel E Singer
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jun 30, 2006·Expert Opinion on Pharmacotherapy·Sudesna ChatterjeeMelanie J Davies
Mar 21, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·C M BennettS C Dharmage
May 31, 2007·Diabetes Care·William H HermanUNKNOWN Diabetes Prevention Program Research Group
Aug 23, 2007·Diabetologia·UNKNOWN American Diabetes AssociationUNKNOWN International Diabetes Federation
Oct 31, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·K-S KimY-W Cho
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·S E ManleyJ M Smith
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Mike Mitka
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Oct 8, 2009·Diabetes Care·Esther van 't RietJacqueline M Dekker
Nov 12, 2009·Diabetes Care·Viswanathan MohanK M Venkat Narayan
Dec 17, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·X H ZhouQ Qiao

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Citations

Jun 5, 2012·QJM : Monthly Journal of the Association of Physicians·R Lee, T A Chowdhury
Apr 9, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Nitin N GholapKamlesh Khunti
Feb 23, 2011·Acta Diabetologica·Mohsen Janghorbani, Masoud Amini
Nov 26, 2010·The Journal of Evidence-based Dental Practice·Wenche S Borgnakke
Feb 1, 2013·International Journal of Endocrinology·Moira Strand HutchinsonRolf Jorde
Sep 28, 2010·Primary Care Diabetes·Nitin GholapKamlesh Khunti
Jun 16, 2012·Diabetes Care·Samiul A MostafaKamlesh Khunti
Sep 14, 2016·Diabetes & Metabolic Syndrome·H M M HerathN P Weerasinghe
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
Mar 3, 2015·Diabetes & Metabolism Journal·Jung Min Kim, Dong-Jun Kim
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Andrea MoscaPhilippe Gillery
Jul 10, 2012·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·S A MostafaM J Davies
Sep 12, 2018·Nature Reviews. Endocrinology·Francesco Zaccardi, Kamlesh Khunti
May 23, 2019·Acta Diabetologica·Santiago Rodriguez-SegadeFrancisco Gude
Sep 11, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·W G John, UNKNOWN UK Department of Health Advisory Committee on Diabetes
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ram JagannathanMichael Bergman

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